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In Vivo Pharmacology - Biologic variation, reproducibility and predictability in preclinical drug testing in lab. animal
Provider: Faculty of Health and Medical Sciences
Activity no.: 3120-17-00-00
Enrollment deadline: 01/06/2017
Date and time
19.06.2017, at: 00:00 - 23.08.2017, at: 16:00
Regular seats
24
Course fee
6,480.00 kr.
Lecturers
Jens Lykkesfeldt
ECTS credits
6.00
Contact person
Helle Lohmann Schøler E-mail address: hlsc@sund.ku.dk
Enrolment Handling/Course Organiser
PhD administration E-mail address: phdkursus@sund.ku.dk
Aim and content
This course is free of charge for PhD students at Danish universities (except Copenhagen Business School). Special rules apply for research year students enrolled at Faculty of Health and Medical Sciences at UCPH. All other participants must pay the course fee.
Anyone can apply for the course, but if you are not a PhD student, you will be placed on the waiting list for the course until enrollment deadline. After the deadline of enrollment, available seats will be allocated to students on the waiting list.
Course title
In Vivo Pharmacology: Biologic variation, reproducibility and predictability in preclinical drug testing in laboratory animals
Course extend
6 ECTS points
Learning objectives
A student who has met the objectives of the course will be able to:
a. Understand the basic theoretical foundation on in vivo pharmacological testing including both screening and confirmatory methods
b. Apply knowledge of and discuss biological and experimental variation, reproducibility and predictability related to animal experiments
c. Engage in designing laboratory animal experiments.
d. Discuss and reflect on validity of animal models of human disease
Content
Experimental research in animals is justified due to its expected predictability of conditions in other species. Within the same species and even within the same strain or substrain of a species, the variation can be large. This phenotypic variation is not only ruled by the genotype but also by environmental factors as simple as housing conditions, feeding and microbiological status. Integration of study results obtained by animal experimentation is generally accepted as valid. However, due to many factors influencing the experimental outcome, contradictory results may be obtained and sometimes great difficulties have been experienced in reproducing results obtained by other investigators.
The uncertainties in animal characteristics and testing conditions so far have not hindered the insight into biological regulatory mechanisms. However, if animal studies should have the highest degree of predictability and reproducibility, only animals of well-defined health status housed under well-defined conditions should be used. In vivo drug testing should be planned in order to eliminate the variation caused by improper standardisation from group to group or over time and the bias caused by erroneous techniques.
This course will highlight the various factors that are critical for variation and thereby for the reproducibility and predictability in experimental research in animals. The factors are many and some are more important than others. The importance may vary with the goal and design of the study. It is the responsibility of the scientists to take these factors into consideration in order to produce data that offer minimal experimental variation and maximal reproducibility. Taking this responsibility seriously will not only improve drug testing, but it will also be in accordance with the ethical obligation to gain as much information as possible whenever using animals for experiments.
Covered topics include:
• In vivo models in pharmacology and toxicology
• Experimental design
• Validity of animal models
• Variation in animal experiments: Factors related to the animal
• Variation in animal experiments: Factors related to the environment
• Variation in animal experiments: Experimental factors
• New tools and clinical perspectives
Participants
The course is relevant for student with a veterinary, medical or natural science degree planning to do animal experiments or enrolled in the In Vivo Pharmacology PhD program. It is an advantage to have passed the Laboratory animal science course or equivalent.
Language
English
Form
Lectures, exercises, discussions, poster presentations and group work. In addition, substantial self-study, preparation of poster with an in vivo pharmacological perspective, and evaluation of fellow student’s work is included
Course director
Professor Jens Lykkesfeldt, Department of Veterinary Disease Biology, Section of Experimental Animal Models, Frederiksberg Campus, KU-SUND, E-mail: jopl@sund.ku.dk
Teachers
Teachers from both academia and pharmaceutical industry
Course secretary
Helle Lohmann Schøler, hlsc@sund.ku.dk
Course dates and venue
Part 1: 19/6 – 23/6 2017 Part 2: Poster session and examination 21/8 & 23/8 2017
KU-SUND, Frederiksberg Campus
Registration: Please register before (01.06.2017)
Admission to PhD students from Danish universities will be allocated on a first-come, first-served basis and according to the rules in force.
IMPORTANT: Non-PhD student participants should submit application directly to the course secretariat (Helle Lohmann Schøler, hlsc@sund.ku.dk), i.e. NOT register on the graduate school homepage. Course fee for external participant is DKK 10,500.00.
Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.
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