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Peptide Chemistry
Provider: Faculty of Science

Activity no.: 5780-18-10-31 
Enrollment deadline: 23/11/2018
Date and time26.11.2018, at: 00:00 - 07.12.2018, at: 16:00
Regular seats15
LecturersKnud Jørgen Jensen
ECTS credits8.00
Contact personLone Mortensen    E-mail address: lone@chem.ku.dk
Enrolment Handling/Course OrganiserKnud Jørgen Jensen    E-mail address: kjj@chem.ku.dk
Written languageEnglish
Teaching languageEnglish
Semester/BlockBlock 2
Block noteNovember 2018 - January 2019
Exam requirementsPhD student (Advanced MSc student) Students must submit a report by 15 January 2019.
Exam formA report on an agreed topic followed by an oral presentation
Grading scalePassed / Not passed
Course workload
Course workload categoryHours
Lectures30.00
Paper60.00
Report writing100.00
Preparation of presentation8.00
Preparation2.00
Sum200.00
Aim and content

The aim of the course is to teach PhD students peptide chemistry at an advanced level. The topics will include:

• Peptide and protein structure: conformation and protein architecture
• Peptide synthesis: protecting groups, coupling reagents, and solid supports
• Classics in peptide synthesis
• Strategies and tactics in peptide synthesis
• Disulfide linked peptides, glycopeptides, and phosphopeptides
• Chemical protein synthesis: chemoselective ligation
• Biophysical characterization: NMR, CD, fluorescence
• Foldamers, incl. ?pPeptides
• Peptidomimetics and turn mimics
• De novo protein design
• Peptide drugs
• Applications of synthetic peptides

Learning outcome
To give an exhaustive description of peptide structure and conformation
To give an exhaustive description of protecting groups and chemical reagents for solid-phase peptide synthesis
To have a thorough understanding of chemistry for amide bond formation in solid-phase peptide synthesis
To give an overview of peptide medicinal chemistry
To be familiar with solid-phase peptide synthesis of complex and modified peptides
To have a good understanding of posttranslationally modified peptides
To have a good understanding of main principles of peptide medicinal chemistry
To be familiar with the uses of synthetic peptides

Lecturers
Knud J. Jensen, kjj@chem.ku.dk
Paul R. Hansen, prh@sund.ku.dk

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