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Organic chemistry in the pharmaceutical, agrochemical and contract manufacturing industries
Provider: Faculty of Science

Activity no.: 5781-19-10-33 
Enrollment deadline: 11/11/2019
PlaceDepartment of Chemistry
Universitetsparken 5, 2100 København Ø
Date and time11.11.2019, at: 00:00 - 15.11.2019, at: 16:00
Regular seats250
ECTS credits5.00
Contact personMichael Pittelkow    E-mail address: pittel@chem.ku.dk
Enrolment Handling/Course OrganiserMichael Pittelkow    E-mail address: pittel@chem.ku.dk
Written languageEnglish
Teaching languageEnglish
Course workload
Course workload categoryHours
Course hours125.00
Sum125.00
Content
A one-week PhD-course taking place at University of Copenhagen that will also be open to MSc students, BSc students, postdocs, and any interested academic and industrial chemists.

Joint lunch will be served on each day to allow maximum interaction between course participants and speakers.

Thursday afternoon of the course (November 14th, 2019), all course participants and any speakers still present in Copenhagen will be invited to attend a student poster session followed by a joint course dinner.

Presentation of a student poster is voluntary for all student course participants but of course strongly encouraged, both for the learning experience of preparing a poster but in particular also to engage in detailed project discussions with all the other course participants.

Overall course program (will be finalized as soon as all remaining lecturers are confirmed):

Monday: Introduction, Structural Properties, and Small-Molecule Medicinal Chemistry
Lecture 1: Four Decades in Pharmaceutical Research, Prof. Dr. Klaus Müller, Roche Distinguished Scientist, Roche, Basel, Switzerland (retired since 2015)
Lecture 2: Conformational Caveats and Opportunities in Molecular Design, Prof. Dr. Klaus Müller, Roche Distinguished Scientist
Lecture 3: Title TBC, Dr. Morten Jørgensen, Research Fellow, Department of Medicinal Chemistry, H. Lundbeck A/S, Valby, Denmark – still TBC
Lecture 4: Title TBC, Dr. Philip Skaanderup, Research Investigator, Novartis Pharma AG, Basel, Switzerland
Lecture 5: Title TBC, Medicinal chemistry speaker from Astra-Zeneca TBC, Sweden

Tuesday: Small Molecule Process Chemistry in the Pharmaceutical Industry
Lecture 1: Battling with Triple-O-Seven – Route Scouting and Early Scale-up, Dr. Martin Juhl, Senior Specialist, Department of Process Chemistry, H. Lundbeck A/S, Valby, Denmark
Lecture 2: Title TBC, Dr. Florian Kleinbeck, Research Fellow, Process Chemistry, Novartis Pharma AG, Basel, Switzerland
Lecture 3: Modularity in ligand design – from well-established to modern catalysis, Dr. Jürgen Rotzler, Head Operations BU Ligands & Specialty Products, Solvias AG, Basel, Switzerland
Lecture 4: Turning data into results and 30 kg RG7834, Dr. Georg Wuitschik, Senior Scientist, Pharma Technical Development, Roche, Basel, Switzerland
Lecture 5: Title TBC, Dr. Robert Woodward, Team Manager, Process Development, Astra-Zeneca, Macclesfield, United Kingdom

Wednesday: Protein Chemistry, Biopharmaceuticals, and Agrochemicals
Lecture 1: Modified Proteins and Peptides for Biopharmaceutical Drug Development, Prof. Dr. Thomas E. Nielsen, Director of Research Chemistry, Novo Nordisk A/S, Måløv, Denmark
Lecture 2: Peptide and Protein Chemistry Development at Novo Nordisk, Dr. Per Vedsø, Team Leader Chemical Process Development, CMC API Development, Novo Nordisk A/S, Måløv, Denmark
Lecture 3: Process Development and Manufacturing of Antibody Drug Conjugates, a Promising Class of Targeted Anti-Cancer Drugs, Dr. Bernhard Stump, Head of Process Development Bioconjugates, Lonza Custom Development, Visp, Switzerland
Lecture 4: Title TBC, Dr. Steen Saaby, Ronland Technology Implementation Manager, FMC Chemicals, Denmark - still TBC
Lecture 5: Agrochemicals from discovery phase to multi ton-scale manufacturing – exact title TBC, Speaker from Syngenta, Stein, Switzerland

Thursday: The Biotech Industry and Contract Manufacturing Organizations
Lecture 1: Academic entrepreneurship: Experiences from founding UNION Therapeutics, Prof. Dr. Morten Sommer, DTU Biosustain and Chief Scientific Officer at UNION Therapeutics, Hellerup, Denmark
Lecture 2: Locked Nucleic Acid: A Biotech and Technological Perspective, Dr. Troels Koch, VP and Head of Research, Roche Innovation Center Copenhagen, Denmark (until January 2019)
Lecture 3: From molecule to a marketed product, Dr. Umar Hayat, HP Consulting, San Francisco, USA
Lecture 4: How to create a niche business in a globalized competitive industry? Do things that others don’t, Dr. Thomas Fessard, Chief Executive Officer, SpiroChem AG, Basel, Switzerland
Lecture 5: Scaling up Biotransformations, Prof. Dr. Tom Moody, Vice President, Technology Development and Commercialisation, Arran Chemical Company and Almac Sciences, Craigavon, Ireland
Lecture 6: Molecular modeling in pharmaceutical development, Prof. Dr. Per-Ola Norrby, Principal Scientist, Pharmaceutical Sciences, Astra-Zeneca, Gothenburg, Sweden

Late Thursday afternoon and evening:
Student poster session including poster prizes, drinks and socializing & informal symposium dinner/Pizza&Beers (100% pure Danish “hygge”!)

Friday: Solid state properties, CMC analytical development, human degradation of drug candidates, and take-home messages and outlook

Lecture 1: Solid state characterization of new drug molecules. What is that and why is it so important, Heidi Lopez de Diego, Chief Specialist in Solid State Characterization, H. Lundbeck A/S, Valby, Denmark
Lecture 2: Preparation for first in human clinical trials - from an analytical point of view, Henrik Nicolaisen, Analytical Development Specialist, H. Lundbeck A/S, Valby, Denmark
Lecture 3: Human degradation of drug candidates – the need for synthesizing and investigating human metabolites, Dr. Lisbet Kvaerno, Head of Synthetic Chemistry, Hypha Discovery Ltd, Slough, United Kingdom
Lecture 4: Take-Home Messages and Outlook, Prof. Dr. Klaus Müller, Roche Distinguished Scientist, Roche, Basel, Switzerland (retired since 2015)
Lecture 5: Conclusions FDA (From Different Angles), Prof. Dr. Klaus Müller, Roche Distinguished Scientist

Learning outcome
Knowledge about relevant industry career choices and experiences that can help shape a career after completion of a university degree or postdoctoral study in organic chemistry.

Contemporary case stories throughout the pharmaceutical, agrochemical and contract manufacturing industries that will be of future use to all organic chemists, whether in industrial or academic positions

Literature
All lectures will be provided in pdf-format to all course participants subsequent to the course for post-course evaluation (self-study)

Remarks
Place: Auditorium 1, Department of Chemistry, Universitetsparken 5, 2100 København Ø

Registration: Registration for this course will open from May 2019
Press “Apply” and fill in the application form, including a confirmation which free meals during the course you wish to participate in
Course seats will be filled on a first-come-first-served basis after May 2019 completely independently on the course participant’s current affiliation

Lecturers & course organizers:
Plenary lecturer:
Prof. Dr. Klaus Müller, Roche Distinguished Scientist, Roche, Basel, Switzerland (retired since 2015) http://www.rsc.org/ScienceAndTechnology/Awards/OrganicIndustrialChemistryAward/2011winner.asp

Lecturer and external course organizer: Dr. Lisbet Kvaerno, Head of Synthetic Chemistry, Hypha Discovery Ltd, Burnham, United Kingdom

In addition, 21 lecturers from industry in Denmark, Switzerland, Sweden, United Kingdom and USA will give one lecture each throughout the week

Internal course organizer: Prof. Dr. Michael Pittelkow, Department of Chemistry, University of Copenhagen, Denmark

Activity Prices: PhD Students: Free, including free lunches and free symposium dinner

Any dedicated course sponsors are of course most welcome!

Written language:English
Teaching language: English

Exam requirements: Course participants have the option to sign up with a poster
Exam form: Course participation and post course evaluation (self-study)

Course workload:
Preparation: 50.00 hours
Lectures: 50.00 hours
Colloquia and poster session: 25.00 hours

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