Login for PhD students/staff at UCPH      Login for others
Dynamic Modelling of Toxic Effects
Provider: Faculty of Science

Activity no.: 5713-21-09-31 
Enrollment deadline: 14/08/2021
PlaceDepartment of Plant and Environmental Sciences
Date and timeSeptember 2021 - October 2021
Regular seats40
ECTS credits5.00
Contact personNina Cedergreen    E-mail address: ncf@plen.ku.dk
Enrolment Handling/Course OrganiserNina Cedergreen    E-mail address: ncf@plen.ku.dk
Written languageEnglish
Teaching languageEnglish
Semester/BlockAutumn
Block noteDuration 7,5 days: (5 online sessions of 4 hours a week for five weeks prior to the on-site course: 17-22 Oct.) If the Covid situation prevents travelling, the five days on-site teaching will be converted to on-line teaching.
Scheme group noteSchedule to be determined
Exam formWritten assignment
Exam detailsWritten assignment. The final report must be handed in in time and be accepted by the course convenors
Criteria for exam assessment5 ECTS for the entire course, and 2 ETCS for the online part only. We expect you to prepare for the course in advance and follow the online sessions, and to hand in required report at October 22nd at the latest to receive full credits. Exam period October 2021
Course workload
Course workload categoryHours
Lectures20.00
Theory exercises26.00
Practical exercises10.00
Preparation40.00
Project work40.00

Sum136.00


Content

The toxicity of a chemical not only depends on chemical properties and the exposed species, but also on exposure time, the endpoint measured, and the exposure conditions. Mathematical modelling is a powerful tool to interpret the results of laboratory toxicity tests and to make educated extrapolations. In this course, you will learn the basics of toxicokinetic and toxicodynamic modelling, and how they can be linked. This foundation allows you to analyse and interpret body residue and toxicity data on a mechanistic basis.

A detailed schedule for the content of the specific talks and exercises will be provided in spring. The overall content is given in this summary:
The toxicity of a chemical depends on properties of the compound and of the species that is exposed, but also on the exposure time, the endpoint (e.g. growth, reproduction or survival), and the exposure conditions (temperature, food level, etc.). In ecotoxicology, the interdependencies of these factors are generally ignored by rigid standardisation of the tests and descriptive summary statistics such as EC50 and NOEC. However, we need a more mechanistic interpretation of toxicity to make an unbiased comparison of toxicity between species and chemicals, and to extrapolate the effects to untested exposure conditions. Because it is impossible to test all chemicals on all species under all possible exposure scenarios, extrapolation is of key importance for ecotoxicologists and environmental risk assessors.

Mathematical modelling is a powerful tool to interpret the results of laboratory toxicity tests and to make educated extrapolations. The process of mechanistically modelling toxicity can be divided into two steps: toxicokinetics (TK) and toxicodynamics (TD). TK deals with the uptake, biotransformation and distribution of a chemical into the body of an organism, whereas TD deals with the next step: from internal concentration of the active compound to effects on the organism over time.

In this course, you will learn the basics of TK and TD modelling, and how they can be linked. Furthermore, you will learn to analyse and interpret toxicity data on a mechanistic basis. For TK modelling, we will focus on 1- and 2-compartment models; TD modelling will focus on a simple Dynamic Energy Budget model (DEBkiss), although we will also treat survival modelling with GUTS in the on-line part of the course. The course comprises a combination of lectures, computer exercises and discussions. In the computer exercises you will learn to build and use basic TKTD models yourself in Matlab, guided by a series of general exercises.

The course will be divided into two parts: An at-home and on-line part taking place from September 13th till October 15th, with an on-line meeting each Wednesday afternoon from 13.30-17.00. At these meetings, there will be lectures introducing theory and discussions on the reading materials and exercises. In between meetings, we ask you to study reading materials and make computer exercises to get acquainted with the software and with the topics. The on-line part focusses on TK and TD principles, and more specifically on TK and survival models (GUTS). The second part takes place on site at Danhostel Roskilde Vandrehjem, meeting Sunday October 17th for dinner and a short introduction, and finishing Friday October 22nd after lunch. During the on-site part of the course, we will focus more specifically on sub-lethal effects (with a DEB-based model). Each course day will consist of a mixture of lectures, exercises and group projects, that will help you to master the modeling and interpret your data output



Learning outcome

In this course, students will:

• Understand the concepts of TK and TD (online)
• Understand the basics of mechanistic effect modelling (online)

• Learning to work with the BYOM platform in Matlab (online)

• Build simple TK models, and TD models for survival (online)
• Build TKTD models for sub-lethal effects (on-site)

• Use them to analyse and interpret toxicity data (on-site)
• Analyse a case study, and discuss and interpret the results (on-site)
• Learn to use advanced analysis options with the BYOM platform under Matlab (on-site)


Literature

Jager T, Heugens EHW, Kooijman SALM. 2006. Making sense of ecotoxicological test results: Towards application of process-based models. Ecotoxicology 15:305-314.

Ashauer R, Escher BI. 2010. Advantages of toxicokinetic and toxicodynamic modelling in aquatic ecotoxicology and risk assessment. Journal of Environmental Monitoring 12:2056-2061.

Jager, T.; Martin, B. T.; Zimmer, E. I., DEBkiss or the quest for the simplest generic model of animal life history. Journal of Theoretical Biology 2013, 328, 9-18.

Jager T. (2020). Revisiting simplified DEBtox models for analysing ecotoxicity data. Ecological Modelling 416:108904. https://doi.org/10.1016/j.ecolmodel.2019.108904


More information including references can be found on: www.debtox.info and www.ecotoxmodels.org

 


Teaching and learning methods

Teaching will be a combination of lectures, computer exercises, group projects, and discussions. After both the on-line and on-site parts, we ask the students to perform a specific data analysis at home, individually, and report that to the teachers.

 

Lecturers

Tjalling Jager (DEBtox Research, NL), Roman Ashauer (Syngenta), Neil Sherborne (Syngenta),
Andre Gergs (Bayer),
Andreas Focks (Wageningen University).



Remarks

Price

1000 DKK for on-line part only (13/9-13/10)
5000 DKK academia (MSc and PhD students)
15000 DKK industry

The price covers a full course including breakfast and lunch buffet at the course centre Danhostel Roskilde.

Please note that overnight accommodation are on the participants own expense.

To sign up for the course, please press "apply", fill in the required info and afterwards send a mail to ncf@plen.ku.dk stating your choice of accommodation at Danhostel Roskilde and dietary preferences:

1) no accommodation - NB. dinner at your own expense!

2) accommodation in shared room with 3-6 participants (including dinner) DKK 1500

3) accommodation in single room (including dinner) DKK 3000


Final deadline for application is May 31th or when the maximum number of participants has been reached.
The registration is binding, and the fee and expense of accommodation is non-refundable in case of participant cancellation after deadline 31th of May 2021.

All participants must bring their own lap-top with Matlab (version 2016b or newer) installed.

*
UCPH discloses non-sensitive personal data to course leader/speakers, if any. In addition, we will disclose non-sensitive personal data to the other participants in the course. Non-sensitive personal data includes names, job positions, institution names & addresses, telephone numbers and e-mail addresses

 





Apply  Preview

Course title: 5713-21-09-31 Dynamic Modelling of Toxic Effects

Date: September 2021 - October 2021

[FormularFieldsHelpText]

:*
:*
:*
:*
:*
:*
:*
:* dd.mm.yyyy 
:*
:
Danish postal code (if foreign, type under address): 
:
:*
:*
:*
Search
Click the search button to search Courses.


Course calendar
See which courses you can attend and when
JanFebMarApr
MayJunJulAug
SepOctNovDec



Publication of new courses
All planned PhD courses at the PhD School are visible in the course catalogue. Courses are published regularly.