Faculty of Science

Topics in Statistical Genetics
Provider: Faculty of Science

Activity no.: 7006-22-07-31
	Enrollment deadline: 07/02/2022

Place

Department of Mathematical Sciences

Date and time

07.02.2022, at: 08:00 - 08.04.2022, at: 16:00

Regular seats

ECTS credits

7.50

Contact person

Nina Weisse E-mail address: weisse@math.ku.dk

Enrolment Handling/Course Organiser

Carsten Wiuf E-mail address: wiuf@math.ku.dk

Written language

English

Teaching language

English

Semester/Block

Block 3

Scheme group

Exam form

Written assignment

Exam details

Written assignment, 27 hours Written take-home assignment

Grading scale

7 point grading scale. For PhD students: Passed / Not Passed

Course workload

Course workload category	Hours
Lectures	28.00
Preparation	130.00
Theory exercises	18.00
Practical exercises	3.00
Exam	27.00

Sum	206.00

Content

Introduction to topics in Statistical Genetics, that is, the application of statistical methods for modelling and drawing inferences from genetic data, in particular DNA data. Genetics have been of statistical interest for more than 100 years.

The course discusses mathematical theory and statistical models to understand how genetic data vary in populations and how we can draw infererence from genetic data. Mathematical and statistical theory underlies vast progress and claims made in recent years about human's relationship to Neanderthals, the origin and spread of diseases (such a Covid19), and how the world was populated.

Random variables modelling genetic data from individuals in a population are highly correlated ("exchangeable random variables") and standard asymptotic theory does not apply. The theory and models are based on Markov chains/processes, in discrete and continuous time. Inference procedures are adhoc or advanced, and often based on models with latent variables.

Key mathematical/statistical concepts are ancestral processes, the coalescent process, the age and frequency of alleles (genetic types) in populations, and inference for genetic data based on such processes. Relatedness between indivduals is desribed in terms of a stochastic graph.

Learning outcome

Knowledge:
At the end of the course the student will have knowledge about the use of statistics in genetics, how genetic variation is modelled, ancestral processes, and how inference can be made from such processes.
The student will have the knowledge to explain
- population genetic models, like the simple Wright-Fisher model,
- the coalescent process and Ewens sampling formula
- the frequency distribution of alleles (types)
- statistical methods for inference on genetic data in different situations
- the use of Markov chains to model genetic variation

Skills:
The student will acquire the skills to analysis simple genetic data sets, and to extract basic mathematical properties about ancestral processes.

Competencies:
At the end of the course the students will have the competence to
- carry out inference for (simple) genetic data sets
- extract relevant mathematical properties of genetic models
- extract biological insight from mathematical/statistical models

Literature

Course literature to be decided, but will likely be a mix of research papers and extracts from books.

Teaching and learning methods

Four hours of lectures and three hours of exercises per week for 7 weeks.

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