PhD courses at University of Copenhagen

Drug Delivery
Provider: Faculty of Health and Medical Sciences

Activity no.: 3115-14-00-00
	Enrollment deadline: 01/04/2014

Date and time	19.05.2014, at: 09:00 - 23.05.2014, at: 16:00
Regular seats	20
Course fee	5,760.00 kr.
Lecturers	Camilla Foged
ECTS credits	4.20

Contact person	Janne Steen Kjærulf E-mail address: janne.kjaerulff@sund.ku.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content Drug Delivery Learning objectives The course objectives are i) to give participants an in-depth overview of important fundamental principles for drug delivery and ii) to present methodologies for optimizing delivery of different drug classes ranging from small molecules to complex biologics (peptides, proteins, nucleic acids and vaccines). Content One of the main scientific challenges in pharmaceutical development is to deliver the drug compound in a controlled way at the site of action in a therapeutically optimal amount to obtain the desired pharmacological effect. Drug delivery is challenged by the existence of a variety of barriers related to either intrinsic drug characteristics and/or to the relevant physiological environment in the body. It is of utmost importance to have a basic understanding of the extent to which these barriers affect the drug bioavailability, i.e. the relative rate and amount of the drug which reaches the target site. An undesired low bioavailability may be a result of the presence of physiological or metabolic barriers, which a drug compound has to overcome before reaching the target site. Additional hurdles for drug delivery are e.g. an unfavorable biodistribution profile of the drug, physico-chemical drug properties, and a suboptimal pharmaceutical formulation. Approaches to overcome barriers of drug delivery include the choice of administration route as well as formulation design to modify drug characteristics. When optimizing drug delivery it is important to obtain a fundamental knowledge of the complex drug release characteristics in biological environments, biotransformation, as well as drug transport to the target site. A more rational design of drug compounds and pharmaceutical delivery systems is alo enabled by a better understanding of the structural and dynamic functions of biological membrane barriers, e.g. the interplay between lipid bilayer structure, specific membrane transporters and drug molecules or excipients. The lectures will cover the following key topics: - Biological barriers and administration routes - Metabolic barriers - Physico-chemical characteristics of drug substances - Advanced drug delivery systems and targeting (e.g. lipid- and polymer-based delivery systems) - Delivery of small molecule drugs (e.g. poorly soluble drugs and pro-drugs) - Delivery of biologics (e.g. peptides, proteins, nucleic acids and vaccines) - Membrane biophysics in drug delivery - Imaging in drug delivery - Industrial perspectives on drug delivery - Safety and toxicity of nanocarrier systems - The use of in vitro and in vivo models in drug delivery Participants The course is mainly offered to PhD students who have completed undergraduate courses in pharmaceutics, chemistry or biology. Language English Form Lectures, group work, writing of report, preparation Course directors Camilla Foged, PhD, Associate Professor, Department of Pharmacy, camilla.foged@sund.ku.dk Hanne M. Nielsen, PhD, Assoc. Professor, Department of Pharmacy, hanne.morck@sund.ku.dk Teachers Camilla Foged, Associate Professor, UC-SUND Hanne Mørck Nielsen, Associate Professor, UC-SUND Clive Wilson, Professor, University of Strathclyde Anette Müllertz, Associate Professor, UC-SUND Bente Steffansen, Associate Professor, UC-SUND David Needham, Professor, University of Southern Denmark Raymond Schiffelers, Professor, UMC Utrecht Ulrik Lytt Rahbek, Head of ADME Department, Novo Nordisk A/S Birger Brodin, Associate Professor, UC-SUND Marco van de Weert, Associate Professor, UC-SUND Lassina Badolo, Principal Scientist, Lundbeck A/S Karsten Petersson, Head of Skin Targeting, LEO Pharma Rene Holm, Head of Department, Lundbeck A/S Ken Howard Aarhus University Moein Moghimi, Professor, UC-SUND Thomas Rades, Professor, UC-SUND Course secretary Janne Steen Kjærulff: janne.kjaerulff@sund.ku.dk Dates 19-23 May 2014 Course location U9-U10, Universitetsparken 2