SSAP - Solid state analysis of pharmaceuticals
Provider: Faculty of Health and Medical Sciences

Activity no.: 3163-14-00-00 
Enrollment deadline: 01/10/2014
Date and time01.12.2014, at: 09:00 - 05.12.2014, at: 16:00
Regular seats15
Course fee7,320.00 kr.
LecturersThomas Rades
ECTS credits5.40
Contact personMarianne Wieslander Jørgensen    E-mail address: marianne.joergensen@sund.ku.dk
Enrolment Handling/Course OrganiserPhD administration     E-mail address: phdkursus@sund.ku.dk

Aim and content
Learning objectives
The course objectives are to give participants an in-depth insight into the various standard solid state analytical tools used in the pharmaceutical sciences, including thermoanalytical, diffractometric, spectroscopic techniques, particulate micrometrics and dissolution.

A student who has met the objectives of the course will be able to:

a. understand the importance of solid state properties within pharmaceutics
b. identify and describe relevant phase transitions in pharmaceutical materials (melting, crystallization, polymorphism, glass transition, dehydration, volatiles analysis, moisture content etc)
c. understand molecular level interactions in different solid forms
d. relate particle properties to powder behavior (packing, flowability, fluidization, powder rheology)
e. explain the dissolution behavior of a drug in relation with its solid state properties
f. evaluate crystallographic results and review crystallographic databases
g. reflect on solid state properties influenced by processing stresses and manufacturing procedures
h. use a set of different standard solid state analytical tools
i. evaluate and discuss data obtained from the practical part of the course

Content
The presence of different solid state forms for a given pharmaceutical compounds is of critical importance – processability, dissolution rate and bioavailability are examples of final product characteristics that can be critically affected by these properties.

The lectures will cover the following key topics:
• Structural classifications of pharmaceutical solids
• Disorder and amorphous solids
• Single-crystal X-ray diffraction and Powder X-ray diffraction
• Applications of synchrotron radiation
• Theory and application of Differential Scanning Calorimetry (DSC), modulated DSC (MDSC) and Thermogravimetric Analysis (TGA)
• Theoretical background and application of isothermal microcalorimetry (Thermal Activity Monitoring TAM III)
• Particle size/shape distributions (comparison of different techniques, focus on image analysis) and density with a link to packing, flowability/fluidization and powder rheology (powder rheometers)
• Surface properties (porosity, roughness, surface energy) BET profilometry AFM IGC
• Water solid interactions (sorption/desorption analysis), hydrates + dehydration mechanisms DVS
• Mechanical and dielectric properties (TMA, DMA, Dielectric spectroscopy)
• Introduction to pharmaceutical spectroscopy
• Molecular level characterization using IR, Raman and solid state NMR
• Terahertz pulsed spectroscopy for pharmaceutical applications
• Influence of the solid state properties on solubility and dissolution

Participants
The course is relevant for PhD students with in pharmaceutical sciences.

Language
English

Form
It is a 5-day course comprising about 20 lectures and experimental group works. The group work will be finalized with a report which is due 2 weeks after the course.

Course director
Thomas Rades, KU, thomas.rades@sund.ku.dk
Korbinian Löbmann, KU, korbinian.loebmann@sund.ku.dk

Teachers
Thomas Rades, Professor, KU
Korbinian Löbmann, Assistant Professor, KU
Andrew Bond, Professor, KU
Jukka Rantanen, Professor, KU
Anette Müllertz, Associate Professor, KU
Holger Grohganz, Associate Professor, KU
Clare Strachan, Assistant Professor, University of Helsinki
Yrjö Roos, University College Cork or Kirsi Jouppila, University of Helsinki

Course secretary
Coordinator Marianne W. Jørgensen, Marianne.joergensen@sund.ku.dk

Dates
1 December to 5 December 2014

Course location
Universitetsparken 2, 2100 Copenhagen