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Drug Delivery
Provider: Faculty of Health and Medical Sciences
Activity no.: 3115-15-00-00
Enrollment deadline: 01/04/2015
Date and time
18.05.2015, at: 09:00 - 22.05.2015, at: 16:00
Regular seats
28
Course fee
5,760.00 kr.
Lecturers
Camilla Foged
ECTS credits
4.20
Contact person
Janne Steen Kjærulf E-mail address: janne.kjaerulff@sund.ku.dk
Enrolment Handling/Course Organiser
PhD administration E-mail address: phdkursus@sund.ku.dk
Aim and content
Learning objectives
The course objectives are i) to give participants an in-depth overview of important fundamental principles for drug delivery and ii) to present methodologies for optimizing delivery of different drug classes ranging from small molecules to complex biopharmaceuticals (peptides, proteins, nucleic acids and vaccines).
Content
One of the main scientific challenges in pharmaceutical development is to deliver the drug compound in a controlled way at the site of action in a therapeutically optimal amount to obtain the desired pharmacological effect. Drug delivery is challenged by the existence of a variety of barriers related to either intrinsic drug characteristics and/or to the physiological environment in the body. It is essential to have a basic understanding of the extent to which these barriers affect the drug bioavailability, i.e. the relative rate and amount of the drug which reaches the target site.
An undesired low bioavailability may be a result of the presence of physiological or metabolic barriers, which a drug compound has to overcome before reaching the target site. Additional hurdles for drug delivery are e.g. an unfavorable biodistribution profile of the drug, physico-chemical drug properties, and a suboptimal pharmaceutical formulation.
Approaches to overcome barriers of drug delivery include the choice of administration route as well as formulation design. When optimizing drug delivery it is important to obtain a fundamental knowledge of the complex drug release characteristics in biological environments, biotransformation, as well as drug transport to the target site. A more rational design of drug compounds and pharmaceutical delivery systems is also enabled by a better understanding of the structural and dynamic functions of biological membrane barriers, e.g. the interplay between lipid bilayer structure, specific membrane transporters and drug molecules or excipients.
The course will cover the following key topics:
• Biological barriers and administration routes
• Metabolic barriers
• Physicochemical characteristics of drug substances
• Advanced drug delivery systems, targeting and stimuli-triggered release (e.g. lipid- and polymer-based delivery systems)
• Delivery of small molecule drugs (e.g. poorly soluble drugs and pro-drugs)
• Delivery of biopharmaceuticals (e.g. peptides, proteins, nucleic acids and vaccines)
• Membrane biophysics in drug delivery
• Imaging in drug delivery
• Industrial perspectives on drug delivery
• Safety and toxicity of nanocarrier systems
• The use of in vitro and in vivo models in drug delivery
Participants
The course is mainly offered to PhD students who have completed undergraduate courses in pharmaceutics, chemistry or biology.
Language
English
Form
Lectures, group work, writing of report, preparation
Course directors
Camilla Foged, PhD, Associate Professor, Department of Pharmacy, camilla.foged@sund.ku.dk
Hanne M. Nielsen, PhD, Assoc. Professor, Department of Pharmacy, hanne.morck@sund.ku.dk
Teachers
Camilla Foged, Associate Professor, UC-SUND
Hanne Mørck Nielsen, Associate Professor, UC-SUND
Clive Wilson, Professor, University of Strathclyde
Anette Müllertz, Associate Professor, UC-SUND
Bente Steffansen, Associate Professor, UC-SUND
David Needham, Professor, University of Southern Denmark
Raymond Schiffelers, Professor, UMC Utrecht
Ulrik Lytt Rahbek, Head of ADME Department, Novo Nordisk A/S
Birger Brodin, Associate Professor, UC-SUND
Marco van de Weert, Associate Professor, UC-SUND
Lassina Badolo, Principal Scientist, Lundbeck A/S
Karsten Petersson, Head of Skin Targeting, LEO Pharma
Rene Holm, Head of Department, Lundbeck A/S
Ken Howard Aarhus University
Moein Moghimi, Professor, UC-SUND
Thomas Rades, Professor, UC-SUND
Course secretary
Janne Steen Kjærulff: janne.kjaerulff@sund.ku.dk
Dates
18-22 May 2015
Course location
U9-U10, Universitetsparken 2
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