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Protein Research and Critical Thinking
Provider: Faculty of Health and Medical Sciences

Activity no.: 3811-17-00-00
Enrollment deadline: 06/10/2017
Date and time10.11.2017, at: 08:00 - 01.12.2017, at: 16:00
Regular seats25
ECTS credits2.50
Contact personCarlotta Marasini    E-mail address: carlotta.marasini@sund.ku.dk

Aim and content
Learning objectives
A student who has met the objectives of the course will be able to:

1. Describe emerging themes in protein research
2. Have a foundation to critically analyze data from primary literature in protein research
3. Describe common methods used in the characterization of protein interactions and localization in living cells
4. Explain how experiments in the primary literature investigating proteins were performed
5. Discuss the positive and negative controls that are or should have been used in the primary literature investigating proteins
6. Evaluate whether or not a particular series of experiments warrants the conclusion made by the authors of a study

Content
The practice of clinical medicine is currently being revolutionized by rapid and extraordinary technological advances in molecular and cellular biology that have led to an unprecedented understanding of the molecular basis of human disease. Translating this knowledge into new clinical procedures and treatments demands a deeper understanding of disease-related proteins and their function.
Proteins are the main effectors of cellular function. Their myriad functions include safeguarding the stability of our genome, being the structural and enzymatic components of the cell, and serving as cell-surface receptors and growth factors that mediate cell and tissue communication. Detailed mechanistic studies of how genetic alterations affect protein function, how proteins interact within pathways to affect cell behavior, and how post-translational modifications such as phosphorylation and ubiquitination serve to regulate disease signaling pathways will contribute to the progress of translational research within medicine and provide important insights that may be used to develop new treatment modalities.
The course brings together a group of experienced researchers to provide training on how to analyze data and think critically about state-of-the-art techniques in cellular, molecular, and computational biology characterizing protein mechanisms of action in living cells. Specifically, the content of the course will focus on discussing primary literature from current topics in proteomic analysis of cell signaling, systems and network biology, structural biology, and genome stability.

Participants
Ph. D. –level students with a B.Sc. and/or M.Sc. degree in any biological science or chemistry are eligible to apply. The course is limited to a maximum of 25 participants.

Relevance to graduate programmes
The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH:

Molecular Mechanisms of Disease

Language
English

Form
Students will participate in four group literature discussion sessions led by leading researchers in several fields of protein research, from the Novo Nordisk Foundation Center for Protein Research at the University of Copenhagen. Literature discussion sessions will take place weekly on Fridays for four weeks. A week before each session, a problem set of relevant scientific papers and questions based on their content will be provided. Students must then read the papers critically and submit a written report comprising the answers to the set questions before the discussion session. The discussion will then be based on the problem set. Evaluation (pass/fail) will take into account participation in discussion sessions and written work.

Course director
Jakob Nilsson, Professor, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen

Teachers
Group Leaders from the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen: http://www.cpr.ku.dk/

Dates
Three-hour discussion sessions on the following dates. Extensive reading of current literature (approx. 6-8 hours per session) and preparation of a written report are required in advance of each.
Friday 10 November, 2017
Friday 17 November, 2017
Friday 24 November, 2017
Friday 01 December, 2017

Course locations
Panum Institute, University of Copenhagen, Norre Alle 20, 2200 København

Registration
Please apply before 6 October, 2017. Use this form: http://tinyurl.com/RegiProteinDiscussion to provide your name, email address, the university and PhD program where you are currently enrolled, and a 150 word (max.) statement of your motivation for applying for this course. You will be notified about your registration by email soon after the deadline. Contact amelia.green@cpr.ku.dk with any questions.

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