Graduate School of health and Medical Sciences

Biological Membranes
Provider: Faculty of Health and Medical Sciences

Activity no.: 3146-18-00-00
	Enrollment deadline: 01/10/2018

Date and time	16.11.2018, at: 09:00 - 23.11.2018, at: 16:30
Regular seats	16
Course fee	8,280.00 kr.
Lecturers	Birger Brodin Harald S. Hansen
ECTS credits	5.00

Contact person	Janne Steen Kjærulf E-mail address: janne.kjaerulff@sund.ku.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School). All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student, you will be placed on the waiting list for the course until enrollment deadline. After the deadline of enrollment, available seats will be allocated to students on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1. The student will have gained a general understanding of the structure and function of membrane lipids and transport proteins, and their role as drug targets and interaction with drug delivery systems and active pharmaceutical ingredients (API's). 2. The student will be able to discuss, and perform a critical judgement of, scientific litterature and presentations within the field. 3. The student will be able to relate her/his own research to the overall paradigms within the field, and will have gained some presentation/discussion skills in presentation of her/his own results in oral form. Please describe the students’ learning objectives in terms of; knowledge, skills and/or competences. Depending on the course curriculum, the distribution between the learning objectives may vary. Knowledge; The students will gain an in-depth knowledge of membrane lipids, membrane biophysics, transporter proteins and transporter protein function. This will be coupled with a knowledge of interactions at the level of signal transduction pathways and effector systems, which give the students and understanding of how molecular mechanisms can be integrated into an overall physiological response. The participant be able to analyze the roles of these molecular mechanisms in pathophysiology. Skills; The students will obtain skills to explain, analyze and argue in scientific discussions of both their own work (presented at the beginning of the course) and of subjects treated during the course. Special emphasis is given to this, in dedicated discussion sessions. Furthermore, we aim to promote critical thinking and reflections on scientific results and paradigms, and thus encourage students to participate in discussions after scientific presentations by lecturers. Competencies; The students will gain a broader view of the field of membrane biophysics, transport protein and receptor function and related signal transduction pathways. This will give them the ability to reflect critically on subject matters within the filed, evaluate scientific soundness of experimental results and put them into a larger perspective within drug delivery and function. Content Studies on the biochemistry, biophysics and the barrier function of biological membranes are in rapid progress. An understanding of the structural and dynamic functions of the membranes (e.g. plasma membranes and intercellular membranes in the stratum corneum) may add to a more rational design of drug substances with improved permeation characteristics or specific membrane effects. Membrane transport proteins are important both as pharmacological targets and as potential drug delivery pathways. Membrane receptors are important drug targets, and may also be of importance as drug uptake pathways. The course will deal with biological membranes and their embedded transport and receptor proteins from a pharmacological and pharmaceutical point of view. The course will cover various aspects of the following topics; • Structure and function of biological membranes • Physiological structures in the plasma membrane • Transport and receptor proteins in the plasma membrane • Drug substances acting on biological membranes/transporters • Structure and function of barrier tissues • Strategies to improve transport of drugs across biological membranes and barrier tissues • Membrane lipids as precursors of bioactive molecules Participants The course is aimed at PhD-students within the life sciences, performing research related to biological membranes/transport proteins/receptor proteins, and with an interest in pharmacology and/or pharmaceutics. The students should have a Masters degree within the natural sciences or an equivalent curriculum. Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: All graduate programmes. Language The course language is English Form The course will contain lectures by internationally recognised researchers within their respective fields, oral presentations, essay writing and group discussions. Course director Harald S. Hansen, PhD. Professor, Department of Drug Design and Pharmacology, Pharmaschool, The Faculty of Health and Medical Sciences, University of Copenhagen. Email; hsh@sund.ku.dk Birger Brodin, PhD. Associate Professor, Department of Pharmacy, Pharmascool, The Faculty of Health and Medical Sciences, University of Copenhagen. Email; birger.brodin@sund.ku.dk Dates 16-23/11 2018 Course location TBD, PharmaSchool, Universitetsparken 2/Jagtvej 160, 2100 Copenhagen Registration Please register before 1/10 -2018 Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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