Graduate School of health and Medical Sciences

Preclinical animal research models - and how not to get lost in translation
Provider: Faculty of Health and Medical Sciences

Activity no.: 3161-18-00-00
	Enrollment deadline: 06/05/2018

Date and time	29.05.2018, at: 09:00 - 31.05.2018, at: 21:00
Regular seats	20
Course fee	4,800.00 kr.
Lecturers	Martin Lauritzen
ECTS credits	3.00

Contact person	Janna Hansen E-mail address: janna.hansen@regionh.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School). All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student, you will be placed on the waiting list for the course until enrollment deadline. After the deadline of enrollment, available seats will be allocated to students on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1. Define experimental standards and guidelines. 2. Theorize on study designs, randomization and blinding. 3. Reflect on preclinical guidelines (specifically the ARRIVE guidelines) and the need to know that a preclinical model must reflect the clinical situation to be useful. 4. Evaluate importance of research reproducibility. 5. Reflect on the use of statistics in preclinical studies (specifically effect size, source of variation, value of p-value). 6. Demonstrate the acquisition of knowledge by assessment of strengths and weaknesses in one’s own project. Content In the scientific community, there is an increasing awareness of the limitations and difficulties in translation of preclinical studies to clinical treatment results. There are many reasons for these difficulties, but everybody agrees that it is necessary to reevaluate preclinical research strategies. In brief, it is equally important to choose the correct preclinical model as to study the model in the right/optimal/unbiased way. One initiative is the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines that aim to improve the reporting of research using animals – maximizing information published and minimizing unnecessary studies. These guidelines have now been implemented in more than 1000 journals worldwide, but we need a more general change of behavior of preclinical researchers. This requires education with the express purpose of saving money and lives. This PhD course aims to enable PhD-student to plan studies of preclinical models that mimic the clinical disease according to established international guidelines, and by use of appropriate design to improve the translational impact of their studies. Participants PhD-students in neuroscience, medicine and pharmacology who works with preclinical models of diseases with translation as a scope. A maximum of 20 PhD students will be accepted for the course. Relevance to graduate programmes The course is relevant to PhD students from the following graduate programs at the Graduate School of Health and Medical Sciences, UCPH: Molecular Mechanisms of Disease In Vivo Pharmacology and Experimental Animals Neuroscience Language English Form Lectures, group work, discussions, exercises. Course director Martin Lauritzen, professor, University of Copenhagen and Rigshospitalet mlauritz@sund.ku.dk Teachers Peter Dalgaard, professor, Copenhagen Business School Jens D. Mikkelsen, professor, University of Copenhagen Ulrich Dirnagl, professor, Humboldt University, Berlin Vikki Hurst, Science Manager - Experimental design, UK National Centre for the replacement, refinement & reduction of animal in research (NC3R). Ulf Toelch, Officer Education, Training & Quality in Research, Humboldt University, Berlin Kirsten Thomsen, senior investigator, University of Copenhagen Dates May 29-31, 2018 Course location Maersk Tower Room 07-15-149 Registration Please register before May 6 Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

Click the search button to search Courses.

See which courses you can attend and when

Jan	Feb	Mar	Apr
May	Jun	Jul	Aug
Sep	Oct	Nov	Dec

New courses
Courses are published regularly. High demand courses are announced in spring and autumn.

Learn which courses are announced on fixed dates