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Extracellular Matrix and Proteolysis in Disease
Provider: Faculty of Health and Medical Sciences

Activity no.: 3425-19-00-00 
Enrollment deadline: 08/02/2019
Date and time11.03.2019, at: 09:00 - 15.03.2019, at: 17:00
Regular seats20
Course fee6,120.00 kr.
LecturersMarie Kveiborg
ECTS credits5.00
Contact personMoMed Team    E-mail address: momed@bric.ku.dk
Enrolment Handling/Course OrganiserPhD administration     E-mail address: phdkursus@sund.ku.dk

Aim and content
This course is free of charge for PhD students at Danish universities (except Copenhagen Business School). Special rules apply for research year students enrolled at Faculty of Health and Medical Sciences at UCPH. All other participants must pay the course fee.
Anyone can apply for the course, but if you are not a PhD student, you will be placed on the waiting list for the course until enrollment deadline. After the deadline of enrollment, available seats will be allocated to students on the waiting list.

Course title
Extracellular Matrix and Proteolysis in Disease

Learning objectives
A student who has met the objectives of the course will be able to:

1. explain multiple functional roles of extracellular matrix components
2. understand how the extracellular matrix is remodeled
3. demonstrate knowledge of proteomic based methods to study extracellular matrix components and their dynamic remodeling
4. demonstrate insight into how perturbed extracellular matrix remodeling contributes to human disease

The extracellular matrix and its dynamic remodeling are decisive factors in several cellular functions and, when dysregulated, give rise to several types of disease. In addition to the essential scaffolding function of extracellular matrix molecules, these structures also harbor secreted or shed proteins, such as growth factors, chemokines and cytokines, and interact with membrane-anchored proteins, including adhesion and growth factor receptors. The consequences of extracellular matrix remodeling are wide-ranging, resulting in activation or inactivation of substrate proteins, or modulation of the substrate’s functional properties. Thus, it is not surprising that the implicated proteases play key roles in normal tissue development and repair, as well as in the pathogenesis of a plethora of diseases.

The course will address a number of structural, biochemical, and cell biological properties of extracellular matrix proteins and the associated proteases, including cutting-edge methodological development in this field of research. Furthermore, it will provide important examples of the contribution of extracellular proteolysis to development and disease - with particular focus on cancer and inflammatory disorders. The course concludes with the participants attending and presenting their individual research projects at a joint scientific conference of the Nordic Societies of Matrix Biology.

Max 20 students with an interest in extracellular matrix biology and proteolysis.

Relevance to graduate programmes
The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH:

Molecular Mechanisms of Disease
Cardiovascular Research
All graduate programmes


Lectures, group work, journal clubs. Attendance and mandatory poster presentation at the joint Nordic Matrix Biology meeting (symposium) (Thursday noon till Friday afternoon)

Course director
Associate Professor Marie Kveiborg, Biotech Research and Innovation Centre (BRIC) (marie.kveiborg@bric.ku.dk); Phone: 3532 5679
Section head Niels Behrendt, Ph.d., DSc., the Finsen Laboratory, Rigshospitalet and BRIC (niels.behrendt@finsenlab.dk); Phone: 3545 6030

Yoshifumi Itoh, Oxford, UK
Oliver Schilling, Freiburg, Germany
Christoph Becker-Pauli, Kiel, Germany
Chris Madsen, Lund, Sweden
Ulrich auf dem Keller, DTU
Daniel Madsen, Herlev University Hospital
John Couchman, BRIC
Alejandro Mayorca, BRIC
Federike Genovese, Nordic Bioscience
Jean-Marie Delaisse, Vejle Hospital
Marie Kveiborg, BRIC

Confirmed speakers at the Nordic Matrix Biology Meeting:
Michale Kjær, Bispebjerg Hospital
Abbas Jafari, Odense University Hospital + ICMM, UCPH
Morten Karsdal, Nordic Bioscience
Taina Pihlajaniemi, Helsinkí, Finland
Clair Baldock, Manchester, UK

March 11-15, 2019, every day from 9-17 + Monday and Thursday evenings for social events.

Course location
BRIC, Copenhagen Biocenter, Ole Maaløesvej 5, 2200 København N
Nordic meeting at Panum, Henrik Dam Auditorium

Please register before January 24th 2019.
Upon acceptance in the course you must register and submit a scientific abstract for the joint Nordic Matrix Biology Meeting. Information about this will be provided shortly after registration deadline.

Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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