Graduate School of health and Medical Sciences

Chemical Biology
Provider: Faculty of Health and Medical Sciences

Activity no.: 3155-20-00-00
	Enrollment deadline: 28/08/2020

Date and time	28.09.2020, at: 08:30 - 09.10.2020, at: 12:30
Regular seats	16
Course fee	12,360.00 kr.
Lecturers	John Nielsen
ECTS credits	10.00

Contact person	Marianne Wieslander Jørgensen E-mail address: marianne.joergensen@sund.ku.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD students at graduate schools in the other Nordic countries. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from Nordic countries. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. Learning objectives This lecture course is a biennial, challenging and up-to-date PhD course in chemical biology and combinatorial methods. Chemical biology is a multidisciplinary research area that combines scientific ideas and approaches of chemistry, biology, medicine and allied disciplines to understand and manipulate biological systems with molecular precision. Combinatorial methods comprise the tools applied to generate both diverse and focused compound libraries of small organic molecules, peptides, their analogues and bioactive or biomimetic compounds. The course is primarily aimed at PhD students working within chemistry at the borderline to biological, pharmaceutical and medical sciences. The chemistry and biology of biopolymers, biomacromolecules and their analogues as well as of bioactive small molecules will be covered. The course also includes hot topics in chemical biology, including biopharmaceuticals and protein medicinal chemistry. A student who has met the objectives of the course will be able to: 1. Understand concepts and methods in chemical biology and how perturbation of biological systems can increase the understanding of complex biological mechanisms. 2. Understand concepts and methods in combinatorial sciences as tools for generation and identification and unraveling biological activity or another desired property. 3. Understand the synthesis and application of biopolymers, biomacromolecules and their analogues in chemical biology. This includes a deeper understanding of the role of carbohydrates in biopharmaceutical chemistry, peptides, nucleic acids, lipids and biomimetics. 4. Recognize new trends in biopharmaceuticals and protein medicinal chemistry. Content The foundation and definitions of chemical biology and combinatorial methods in chemistry. Up-to-date examples of combinatorial methods in chemistry and biology in academic and pharmaceutical research. Chemical and biological studies of biomacromolecules, biopolymers and analogues hereof in research and drug discovery. Demonstration of how chemical biology aids discoveries and developments in biopharmaceuticals and protein medicinal chemistry. Participants PhD students with a good knowledge of chemistry and working within chemistry at the borderline to biological, pharmaceutical and medical sciences. Also, individuals from the pharmaceutical and biopharmaceutical industry, who seek introduction to new concepts and to broaden their view on modern trends in chemical biology. Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: All graduate programmes Language English Form Lectures, discussions, group work and a mandatory participation in the symposium “Hot Topics in Chemical Biology”. Formulation and presentation of a relevant scientific problem within chemical biology and combinatorial methods, reporting in “Grant application style” and defence of final application. In addition, we will have workshops covering “Writing a successful grant application” and a SciFinder workshop with focus on advanced searching relevant for the topics covered by the course. Moreover, a Journal Club will run where the participants will read, critically analyse and present in groups for all participant and the course directors. After the course, we expect each participant to spend approximately 2 weeks writing the scientific report and 10 hours for the one-day defence seminar. Course director Professor Kristian Strømgaard, Associate Professor Stephan Pless and Professor John Nielsen Department of Drug Design and Pharmacology, Universitetsparken 2, 2100 Copenhagen Ø E-mails: kristian.stromgaard@sund.ku.dk, stephan.pless@sund.ku.dk, and john.nielsen@sund.ku.dk Teachers Professor Kristian Strømgaard, Associate Professor Stephan Pless and Professor John Nielsen are anchor men for this course. Additional lectures will be presented by a number of leading national and international experts in the field of chemical biology and combinatorial chemistry. In the past these have included Anette Beck-Sickinger, Leipzig University - Carsten Behrens, Novo Nordisk – Rolf Breinbauer, Graz University of Technology – Thomas Høeg-Jensen, Novo Nordisk – Knud J. Jensen, University of Copenhagen – Morten Meldal, University of Copenhagen – Tom Muir, Princeton University - Peter E. Nielsen, University of Copenhagen – Thomas E. Nielsen, Technical University of Denmark – Ulf Nilsson, Lund University - Christian A. Olsen, University of Copenhagen – Angela Russell, Oxford University - Troels Skrydstrup, University of Aarhus – Trond Ulven, University of Copenhagen – Jesper Wengel, University of Southern Denmark, Odense – Thomas Carell, LMU Munich - Helma Wennermers, ETH Zürich - Dorothea Fiedler, FMP Berlin. Dates 28 September – 9 October 2020, following individual scientific report writing and a mandatory one-day defence seminar on 7 December 2020. The work load has been set at 10 ECTS corresponding to approximately 250 hours Course location PharmaSchool, Universitetsparken 2 / Jagtvej 160, 2100 Copenhagen Registration Please register before 28 August 2020 Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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