Graduate School of health and Medical Sciences

BrainH2O - to manage intracranial pressure in pathology, we must understand brain fluid dynamics in physiology
Provider: Faculty of Health and Medical Sciences

Activity no.: 3258-20-00-00
	Enrollment deadline: 16/07/2021

Date and time	16.08.2021, at: 13:00 - 18.08.2021, at: 16:00
Regular seats	20
Course fee	3,360.00 kr.
Lecturers	Nanna MacAulay
ECTS credits	2.10

Contact person	Nanna MacAulay E-mail address: macaulay@sund.ku.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD students at graduate schools in the other Nordic countries. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from Nordic countries. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1.Understand the clinical challenges of managing elevated intracranial pressure. 2.Understand the basics of fluid dynamics in the mammalian brain (CSF secretion, movement and drainage). 3.Be able to identify the critical knowledge gaps in this scientific field and gain insight into how to address these issues from a translational view point. 4.Be able to bridge between clinical approaches, CSF biomarker analysis, computational modelling and experimental strategies within this research field. 5.Present a poster in a setting with leading international experts on the topic - in a manner that is understandable for such diverse type of researchers as those present at this course. Content Our fragile brain tissue is surrounded by a cranium and submerged in the cerebrospinal fluid (CSF), which together serve to protect the brain from mechanical insult. However, in pathologies such as hydrocephalus and idiopathic intracranial hypertension (IIH), excess fluid accumulates in the brain. As our skull cannot expand with increased brain volume, the intracranial pressure (ICP) increases as a consequence, thus compressing brain tissue and blood vessels. Such brain fluid accumulation is considered a vast clinical challenge. Treatment options are limited to surgical procedures, which are entirely symptomatic, highly invasive and exclusively based on a traditional mechanical perception of the brain's fluid dynamics, which fail to consider the molecular water transport mechanisms. To control the brain fluid dynamics in pathophysiology, it is imperative to understand the mechanisms governing the secretion, movement, and drainage of CSF in health and disease. The field of brain fluid homeostasis is in its infancy. To close this knowledge gap, we consider enhanced interaction between clinicians attending patients with elevated ICP and basic scientists with expertise in fluid and solute movement in the brain (or modeling thereof) an absolute must. The course is organized around a symposium, which aims to bridge the topics of CSF dynamics and clinical management of elevated ICP with two diseases as ‘the models’; Idiopathic intracranial hypertension (IIH) and idiopathic normal pressure hydrocephalus (iNPH). PROGRAM AT A GLANCE Session 1: ICP – how can we treat it, and what are the challenges in the clinic? John Pickard, Cambridge University, UK James Pat McAllister, Washington University School of Medicine, US Christina Kruuse, Herlev-Gentofte Hospital, DK Session 2: iNPH – as an acknowledged diagnosis? Michael Williams, Washington University School of Medicine, US Carsten Wikkelsø, University of Gothenburg, SE Steen Hasselbalch, the Neuroscience Center, Rigshospitalet, DK Session 3: What can we learn from IIH? Kathleen Digre, University of Utah, US Alexandra Sinclair, Birmingham University, UK Session 4: Choroid plexus and its secretory machinery Maria Lehtinen, Boston Children’s Hospital, US Roosmarijn E. Vandenbrouche, VIB, Jeppe Prætorius, Aarhus University, DK Session 5: CSF secretion, ventricular flow, and lymphatic drainage Kristopher Kahle, Yale School of Medicine Nathalie Jurisch-Yaksi, Norwegian University of Science and Technology Steven Proulx, University of Bern, CH Session 6: Paravascular flow of CSF markers Jeff Iliff, University of Washington Medical School, US (Glymphatics) Robert Thorne, Denali Therapeutics & University of Minnesota, US (CNS barriers) Session 7: What can we measure in humans and what can we model? Anders Eklund, Umeå University (ICP dynamics in humans) Gitte Moos Knudsen, the Neurobiology Research Unit, DK (CSF imaging in humans) Maria Elisabeth Rognes, Simula Research Laboratory, NO (Modelling of CSF movement) Bryn Martin, University of Idaho, US (CSF movement modeling) Session 8: CSF biomarkers – what can we achieve with CSF analysis? Anja Hviid Simonsen, the Neuroscience Center, Rigshospitalet, DK Kaj Blennow, Gothenburg University, SE Charlotte Teunissen, Vrije University Amsterdam, NE Participants PhD students in the field of neuroscience with a focus on brain fluid dynamics (clinical, experimental, biochemical, or computational). Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: Neuroscience Language English. Form Lectures, poster presentations, panel discussion (with Shakespeak). Course director Nanna MacAulay, Professor, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen. macaulay@sund.ku.dk Teachers Instructors are leading experts in their distinct field of brain water dynamics (see program above). Dates 16 August (13.00-18.00), 17 August (8.30-18.30), and 18 August (8.30-14.30) Course location Faculty Club, Panum Institute, building 16.6. Registration Please register before 16 July 2021, Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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