Graduate School of health and Medical Sciences

Biological Membranes
Provider: Faculty of Health and Medical Sciences

Activity no.: 3146-20-00-00	There are no available seats
	Enrollment deadline: 01/09/2020

Date and time	13.11.2020, at: 09:00 - 20.11.2020, at: 16:45
Regular seats	16
Course fee	9,240.00 kr.
Lecturers	Birger Brodin
ECTS credits	5.00

Contact person	Janne Steen Kjærulf E-mail address: janne.kjaerulff@sund.ku.dk

Enrolment Handling/Course Organiser	Marianne Wieslander Jørgensen E-mail address: marianne.joergensen@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD students at graduate schools in the other Nordic countries. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from Nordic countries. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1. The student will have gained a general understanding of the structure and function of membrane lipids and transport proteins, and their role as drug targets and interaction with drug delivery systems and active pharmaceutical ingredients (API's). 2. The student will be able to discuss, and perform a critical judgement of, scientific literature and presentations within the field. 3. The student will be able to relate her/his own research to the overall paradigms within the field, and will have gained some presentation/discussion skills in presentation of her/his own results in oral form. Knowledge; The students will gain an in-depth knowledge of membrane lipids, membrane biophysics, transporter proteins and transporter protein function. This will be coupled with a knowledge of interactions at the level of signal transduction pathways and effector systems, which give the students and understanding of how molecular mechanisms can be integrated into an overall physiological response. The participant be able to analyze the roles of these molecular mechanisms in pathophysiology. Skills; The students will obtain skills to explain, analyze and argue in scientific discussions of both their own work (presented at the beginning of the course) and of subjects treated during the course. Special emphasis is given to this, in dedicated discussion sessions. Furthermore, we aim to promote critical thinking and reflections on scientific results and paradigms, and thus encourage students to participate in discussions after scientific presentations by lecturers. Competencies; The students will gain a broader view of the field of membrane biophysics, transport protein and receptor function and related signal transduction pathways. This will give them the ability to reflect critically on subject matters within the filed, evaluate scientific soundness of experimental results and put them into a larger perspective within drug delivery and function. Content Studies on the biochemistry, biophysics and the barrier function of biological membranes are in rapid progress. An understanding of the structural and dynamic functions of the membranes (e.g. plasma membranes and intercellular membranes in the stratum corneum) may add to a more rational design of drug substances with improved permeation characteristics or specific membrane effects. Membrane transport proteins are important both as pharmacological targets and as potential drug delivery pathways. Membrane receptors are important drug targets, and may also be of importance as drug uptake pathways. The course will deal with biological membranes and their embedded transport and receptor proteins from a pharmacological and pharmaceutical point of view. The course will cover various aspects of the following topics; • Structure and function of biological membranes • Physiological structures in the plasma membrane • Transport and receptor proteins in the plasma membrane • Drug substances acting on biological membranes/transporters • Structure and function of barrier tissues • Strategies to improve transport of drugs across biological membranes and barrier tissues • Membrane lipids as precursors of bioactive molecules Participants The course is aimed at PhD-students within the life sciences, performing research related to biological membranes/transport proteins/receptor proteins, and with an interest in pharmacology and/or pharmaceutics. The students should have a Masters degree within the natural sciences or an equivalent curriculum. Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: All graduate programmes Language The course language is English Form The course will include lectures by internationally recognised researchers within their respective fields, oral presentations, essay writing and group discussions. Course director Harald S. Hansen, PhD. Professor Emeritus, Department of Drug Design and Pharmacology, Pharmaschool, The Faculty of Health and Medical Sciences, University of Copenhagen. Email; hsh@sund.ku.dk Birger Brodin, PhD. Professor, Department of Pharmacy, Pharmaschool, The Faculty of Health and Medical Sciences, University of Copenhagen. Email; birger.brodin@sund.ku.dk Teachers Harald S. Hansen, University of Copenhagen Birger Brodin, University of Copenhagen Carsten Uhd Nielsen, University of Southern Denmark David Meredith,Oxford Brookes University Maria Deli, Biological Research Centre of the Hungarian Academy of Sciences Gert Fricker, University of Heidelberg Bente Steffansen, LEOPharma Ingolf Blasig, FMP-Berlin Erik Michael Danielsen, University of Copenhagen J.F.C. Glatz, Cardiovascular Research Institute Maastricht Eva Benfeldt, University of Copenhagen Morten Schallburg Nielsen, University of Aarhus Peter Zygmunt, University of Lund Stephan A. Pless, University of Copenhagen Jens Peter Andersen, Aarhus University Petrine Wellendorph(Louise Thiesen?), University of Copenhagen Anette Müllertz, University of Copenhagen Bente Vilsen, Aarhus University Hans Bräuner-Osborne, University of Copenhagen Mette M. Rosenkilde, University of Copenhagen Carsten Erhardt, Trinity College, Dublin Siv A. Hjort. University of Copenhagen Irina Kratchmarova, University of Southern Denmark Dates 13 - 20 November 2020 Course location TBA, PharmaSchool, Universitetsparken 2 / Jagtvej 160, 2100 Copenhagen Registration Please register before 1 Spetember 2020 Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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