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Basic Neuroscience
Provider: Faculty of Health and Medical Sciences

Activity no.: 3236-20-00-00There are no available seats 
Enrollment deadline: 18/10/2020
Date and time11.11.2020, at: 09:00 - 06.01.2021, at: 15:00
Regular seats17
Course fee7,680.00 kr.
LecturersJakob Sørensen
ECTS credits5.00
Contact personAnette Studsgård    E-mail address: studsgaard@sund.ku.dk
Enrolment Handling/Course OrganiserPhD administration     E-mail address: fak-phdkursus@sund.ku.dk

Aim and content
This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD students at graduate schools in the other Nordic countries. All other participants must pay the course fee.
Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from Nordic countries. After the enrollment deadline, available seats will be allocated to applicants on the waiting list.

Learning objectives
A student who has met the objectives of the course will:

1. have insight into the anatomy and function of the nervous system across all levels of organization.
2. understand the most commonly used methods to investigate the nervous system.
3. understand, analyze and discuss contemporary neuroscience literature.

The morphology and functions of neurons and glia cells.
o The techniques for mapping neuronal connections and networks
o Neuronal transcriptional and translation activity, and axonal transport of proteins
o Demonstration of mRNA and proteins in neurons and glia cells.

The passive and active electrical properties of neurons
o The origin of the resting membrane potential
o The molecular and electrical basis for the action potential

The properties of synaptic transmission and plasticity
o Transmission at the chemical and electrical synapse.
o The basis for excitation and inhibition, and their interaction.
o Short-term synaptic plasticity: facilitation and depression
o Long-term changes in synaptic strenght and implications for learning.

The use of animal models to study normal and pathological neuronal signaling
o Small genetic model systems
o Mammalian genetic models
o Models based on other principles (e.g. lesioning of specific brain areas)
o Possibilities and limitations in modeling human neurological and psychiatric disease

Layout and Function of the monoaminergic systems
o Anatomy of the dopaminergic, serotonergic and noradrenergic systems
o What does dopamine signal: hedonia, learning, and incentive salience?
o Molecular composition of dopaminergic signalling
o Drugs of abuse: mechanisms of action
o Serotonine and motor control, mood disorders etc.

The emerging roles of glia cells
o Types of glia and their function.
o Roles of glia cells in LTP
o signaling processing in glia

The physiology of micro-, mesoscale-circuits and systems
o Principles of sensory processing and motor control.
o Circuit design by synaptic properties, intrinsic neuronal membrane properties and connections, examplified by, e.g., CPGs and cortical circuits.
o methods for behavioral and physiological analysis of small circuits and brains, e.g. optical recordings of ensemble behavior of neurons, neuronal synchronization and rhythmicity, optogenetics, EEG, connectomics, genetics.

The higher cortical functions
o Techniques for assessing higher cognitive processes
o Principles of macro-structural cortical organization with an emphasis on the visual system.
o Brain mechanisms of emotion, memory and attention
o Brain Plasticity

The course offers a broad overview of the nervous system, and common physiological techniques used to study it at different levels of organization (the single neuron/cell, smaller and larger circuits, the whole brain). It further trains the students in reading contemporary neuroscience research literature It aims at those Ph.D. students, who would like to add a broad neuroscience course to their C.V. It is less suitable for those Ph.D.-students, who already have a solid neuroscience background.
The course is offered also as a Master’s course on the Human Biology Education (called ‘Neuronal Signalling’). Ph.D.-students, who have previously followed the Master’s course cannot follow the Ph.D.-course.
Describe the target group of the course and required qualifications (if any) by the participating PhD students.

Relevance to graduate programmes
The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH:

All graduate programmes


Lectures, demonstration exercises, literature seminars and discussions.

Course director
Jakob Balslev Sørensen, Professor, Center for Neuroscience, jakobbs@sund.ku.dk

Jakob Balslev Sørensen, Professor, Department of Neuroscience.
Claire Francesca Meehan, Associate Professor, Department of Neuroscience.
Kenneth Lindegaard Madsen, Associate Professor, Department of Neuroscience.
Jens Christian Rekling, Associate Professor, Department of Neuroscience.
Jean-Francois Perrier, Associate Professor, Department of Neuroscience.
Ole Kjærulff, Associate Professor, Department of Neuroscience.
Henrik Jahnsen, Associate Professor, Department of Neuroscience.

11. Nov. 2020 (9:15-17:00); 18. Nov. 2020 (9:15-15:00); 25. Nov 2020 (9:15-15:00), 2. Dec. 2020 (9:15-15:00); 7. Dec. 2020 (13:15-15:00); 9. Dec. 2020 (9:15-17:00); 16. Dec. 2020 (9:15-16:00); 6. January 2021 (9:15-15:00). Changes might occur.

Course location
Panum Building and Maersk Tower, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N.

Please register before 18 October 2020

Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules.
Applications from other participants will be considered after the last day of enrolment.

Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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