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Brain fluid transport: Theoretical considerations
Provider: Faculty of Health and Medical Sciences

Activity no.: 3477-21-00-00There are no available seats 
Enrollment deadline: 04/09/2021
Date and time04.10.2021, at: 08:00 - 07.10.2021, at: 16:00
Regular seats12
Course fee5,280.00 kr.
LecturersMaiken Nedergaard
ECTS credits2.50
Contact personAnne Lee Berger Christensen    E-mail address: ann.christensen@sund.ku.dk
Enrolment Handling/Course OrganiserPhD administration     E-mail address: fak-phdkursus@sund.ku.dk

Aim and content
This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD students at graduate schools in the other Nordic countries. All other participants must pay the course fee.

Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from Nordic countries. After the enrollment deadline, available seats will be allocated to applicants on the waiting list.

Learning objectives
A student who has met the objectives of the course will be able to:

1. Explain the proposed biological utility of brain fluid transport and the evidence for it.
2. Understand diffusion as a transport mechanism, the conditions for diffusive transport in the brain, and its implications there.
3. Understand advection as a transport mechanism, the conditions for advective transport in the brain, and its implications there.
4. Describe emerging methods for quantifying brain fluid transport and the interactions between diffusion and advection.

Four graduate-level pedagogical lectures will focus on the learning objectives:

1. Introduction. Biological utility of brain fluid transport and evidence for it. Methods for measuring brain fluid transport, including MRI, PET/SPECT, transcranial imaging, 2-photon microscopy, electron microscopy, light sheet microscopy, and dessication. Strengths and limitations of each. Common tracers, with strengths and limitations.

2. Diffusion. Mechanistic understanding, including when it occurs and when it does not. Typical values and variation of diffusivity, porosity, and tortuosity, for different chemical species and in different parts of the skull. Solute conservation and its implications. Diffusion measurement methods and results.

3. Advection. Mechanistic understanding, including when it transports material and when it does not. Relation to pressure. Typical values of velocities and pressures. Continuity and its implications, including compartment models. Common drivers of flow in biological systems: gravity, peristalsis, CSF flow in spine, pumping with valves (heart, lymph vessels), lung expansion/contraction, osmosis.

4. Synthesis. Interactions between diffusion and advection. P├ęclet number and its variations in different parts of vascular networks. Hypotheses for brain waste removal by CSF flow, including drivers. Possible and known influx and efflux routes. AQP4. Analysis and theory, including pharmacokinetic / control volume methods, particle tracking, PIV, front tracking, optical flow, and finite-element simulation.

Before the four pedagogical lectures, students will benefit from two days of conference-style presentations from international leaders in the field, each speaking about new research results and recent publications. The presentations will comprise the workshop "The Glymphatic System: From Theoretical Models to Clinical Applications Abstract," supported with additional funds already committed by the Lundbeck Foundation. The conference-style presentations will take place over two days, preceding the four pedagogical lectures. Workshop themes include flow in brain perivascular spaces, flow in the neuropil, preclinical disease models, and fluid transport models.

Basic neuroscience knowledge is required. The course will primarily attract PhD students specializing in neuroscience, but other PhD students focused on biological fluid dynamics, analysis, and modelling will also have interest.

Relevance to graduate programmes
The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH:

Medical and Molecular Imaging
Molecular Mechanisms of Disease


Pedagogical lectures: Each of the numbered topics listed under "Course Content" will be discussed in a separate 60-minute lecture, presented by a leader in the field. Maiken Nedergaard will introduce brain fluid tranport, its proposed utility, and the evidence for it. Charles Nicholson will discuss diffusion. John H. Thomas will discuss advection. Douglas H. Kelley will discuss diffusion-advection interactions and emerging quantification methods. The four lectures will span two days.

Conference-style presentations: Leaders in the field, drawn from around the world, will present recent and relevant research results.

Journal club: The lectures will be complemented by 90-minute journal club sessions to discuss recent literature directly relevant to the lectures. One session will meet each day.

Course director
Maiken Nedergaard, Professor, Center for Translational Neuromedicine, nedergaard@sund.ku.dk

Maiken Nedergaard, Professor, Center for Translational Neuromedicine
Charles Nicholson, Professor Emeritus, Columbia University
John H. Thomas, Professor Emeritus, University of Rochester
Douglas H. Kelley, Associate Professor, Department of Mechanical Engineering, University of Rochester

25 - 28 May 2021

Course location
At Panum, SUND, Blegdamsvej 3B, 2200 Copenhagen N

Please register before 26 April 2021.

Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules.
Applications from other participants will be considered after the last day of enrolment.

Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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