Graduate School of health and Medical Sciences

SSAP - Solid state analysis of pharmaceuticals
Provider: Faculty of Health and Medical Sciences

Activity no.: 3163-21-00-00
	Enrollment deadline: 01/12/2020

Date and time	01.02.2021, at: 08:45 - 05.02.2021, at: 16:00
Regular seats	15
Course fee	11,160.00 kr.
Lecturers	Thomas Rades
ECTS credits	4.00

Contact person	Marianne Wieslander Jørgensen E-mail address: marianne.joergensen@sund.ku.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD students at graduate schools in the other Nordic countries. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from Nordic countries. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1.understand the importance of solid state properties within pharmaceutics 2.identify and describe relevant phase transitions in pharmaceutical materials (melting, crystallization, polymorphism, glass transition, dehydration, volatiles analysis, moisture content etc) 3.understand molecular level interactions in different solid forms 4.relate particle properties to powder behavior (packing, flowability, fluidization, powder rheology) 5.explain the dissolution behavior of a drug in relation with its solid state properties 6.evaluate crystallographic results and review crystallographic databases 7.reflect on solid state properties influenced by processing stresses and manufacturing procedures 8.use a set of different standard solid state analytical tools 9.evaluate and discuss data obtained from the practical part of the course Content The presence of different solid state forms for a given pharmaceutical compounds is of critical importance – processability, dissolution rate and bioavailability are examples of final product characteristics that can be critically affected by these properties. The lectures will cover the following key topics: • Structural classifications of pharmaceutical solids • Disorder and amorphous solids • Single-crystal X-ray diffraction and Powder X-ray diffraction • Applications of synchrotron radiation • Theory and application of Differential Scanning Calorimetry (DSC), modulated DSC (MDSC) and Thermogravimetric Analysis (TGA) • Theoretical background and application of isothermal microcalorimetry (Thermal Activity Monitoring TAM III) • Particle size/shape distributions (comparison of different techniques, focus on image analysis) and density with a link to packing, flowability/fluidization and powder rheology (powder rheometers) • Surface properties (porosity, roughness, surface energy) • Water solid interactions (sorption/desorption analysis), hydrates + dehydration mechanisms, DVS • Mechanical and dielectric properties (TMA, DMA, Dielectric spectroscopy) • Introduction to pharmaceutical spectroscopy • Molecular level characterization using IR, Raman and ssNMR • Terahertz pulsed spectroscopy for pharmaceutical applications • Influence of the solid state properties on solubility and dissolution Participants The course is relevant for PhD students with in pharmaceutical sciences. Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: All graduate programmes Language English. Form It is a 5-day course comprising 21 lectures and experimental group works. The group work will present their work at the end of the course in an oral group presentation and will have to finalize their findings in form of a written report Course director Thomas Rades, Prof., KU, thomas.rades@sund.ku.dk Korbinian Löbmann, Assoc. Prof., KU, korbinian.loebmann@sund.ku.dk Teachers Thomas Rades, Professor, KU Korbinian Löbmann, Associate Professor, KU Natalja Genina, Associate Professor, KU Eric Kissi, PostDoc, University of Oslo Andrew Bond, Professor, University of Cambridge, UK Jukka Rantanen, Professor, KU Anette Müllertz, Associate Professor, KU Holger Grohganz, Associate Professor, KU Flemming Hoffmann Larsen, Associate Professor, KU Clare Strachan, Assistant Professor, University of Helsinki Axel Zeitler, Reader, University of Cambridge, UK Dates 1-5 February 2021 Course location Tbd, Universitetsparken 2, 2100 Copenhagen Registration Please register before 1 December 2020. Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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