Graduate School of health and Medical Sciences

Personalised Medicine and Targeted Therapies: From Concept to Clinical Translation
Provider: Faculty of Health and Medical Sciences

Activity no.: 3266-22-00-00	There are no available seats
	Enrollment deadline: 01/02/2022

Date and time	21.03.2022, at: 08:15 - 28.03.2022, at: 16:00
Regular seats	20
Course fee	7,920.00 kr.
Lecturers	Jose Moreira Alexander Hauser
ECTS credits	4.80

Contact person	Marianne Wieslander Jørgensen E-mail address: marianne.joergensen@sund.ku.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD students at graduate schools in the other Nordic countries. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from Nordic countries. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1. Knowledge: understand the conceptual principles underlying personalised medicine 2. Knowledge: have insight into basic genomic testing concepts and terminology, as well as next-generation sequencing 3. Competences: insight into pharmacogenomics and theorise from these data a suitable therapeutic approach 4. Skills: Able to compare pharmacogenetic tests and assess clinical utility 5. Skills: have methodological insight on how to best identify known heterogeneity within a disease or population and use this information to guide clinical management 6. Competences: Explain driver mutations and companion diagnostics 7. Competences: To put personalised medicine into the larger context of economical, legal, and ethical perspectives Content Personalised medicine (PerMed) is a cross-cutting field that draws on expertise and data from very different disciplines and sectors. PerMed is defined in the European Council Conclusion on personalised medicine for patients (2015/C 421/03) as: “[…] it is widely understood that personalised medicine refers to a medical model using characterisation of individuals’ phenotypes and genotypes (e.g. molecular profiling, medical imaging, lifestyle data) for tailoring the right therapeutic strategy for the right person at the right time, and/or to determine the predisposition to disease and/or to deliver timely and targeted prevention.” Personalised Medicine requires a specific set of knowledge and skills including insight into genomic analysis, rational drug design and their implementation for tailored medical treatments. The course is structured in lectures, guided discussions, with specific practicals, and will cover the following topics: • Human genome structure and importance of genome dynamics in the context of human disease • Genetic variation & genetic disease. Concepts of pathological and neutral variations. Clinical implications • Pharmacogenomics & pharmacogenetics. Adapting genetic knowledge to personalised diagnosis, prognosis, and treatment • PerMed in the context of Drug Design, Pharmacology, and structure biology • Systems pharmacology and Pharmacometrics to understand variability in drug respons • Targeted therapeutics, companion diagnostics, and advanced genome therapeutics • Cancer biology & cancer genetics • Omics methods to enable the selection of optimal screening strategies, interventions or therapies • Legal & ethical scenarios • Health economics Participants PhD students across fields interested in personalised medicine Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: Pharmaceutical Sciences (Drug Research Academy) All graduate programmes Language English Form The course consists of primary lectures, group work and exercides, presentations and discussions. Course director José Moreira, Professor, Department of Drug Design and Pharmacology, jomo@sund.ku.dk Alexander Hauser, Assistant Professor, Department of Drug Design and Pharmacology, alexander.hauser@sund.ku.dk Teachers José Moreira, Professor, Department of Drug Design and Pharmacology Alexander Hauser, Assistant Professor, Department of Drug Design and Pharmacology Vibeke Bjerregaard, Novo Nordisk A/S Volker Lauschke, Karolinska Institutet, Sweden Christiane Gasse, Institute of Clinical Medicin, Aarhus University Britt Elmedal Laursen, Associate Profesor, Aarhus University Jan Trøst Jørgensen, Director – Dx-Rx Institute Anders Hviid, Professor Statens Serum Institut Kristoffer Rohrberg, Head of the Phase 1 Unit at Rigshospitalet Katharina Ó Cathaoir - Associate Professor - Faculty of Law Flemming Steen Jørgensen, Professor, Department of Drug Design and Pharmacology Albert Jelke Kooistra, Assistant Professor, Department of Drug Design and Pharmacology Maurizio Sessa, Assistant Professor, Department of Drug Design and Pharmacology Charlotte Vermehren, Associate Professor, Department of Drug Design and Pharmacology Trine Meldgaard Lund, Associate Professor, Department of Drug Design and Pharmacology Dates 21-28 March 2022 Course location PharmaSchool, University of Copenhagen, Universitetsparken 2/Jagtvej 160, 2100 Copenhagen Registration Please register before 1 February 2022 Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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