Graduate School of health and Medical Sciences

Personalised Medicine and Targeted Therapies
Provider: Faculty of Health and Medical Sciences

Activity no.: 3266-23-00-00
	Enrollment deadline: 01/02/2023

Date and time	20.03.2023, at: 08:15 - 27.03.2023, at: 16:00
Regular seats	24
Course fee	8,040.00 kr.
Lecturers	Jose Moreira Alexander Hauser
ECTS credits	4.80

Contact person	Marianne W. Jørgensen E-mail address: marianne.joergensen@sund.ku.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD Students from NorDoc member universities. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from NorDoc member universities. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. Long title: Personalised Medicine and Targeted Therapies: From Concept to Clinical Translation Learning objectives A student who has met the objectives of the course will be able to: 1. Knowledge: Understand the conceptual principles underlying personalised medicine 2. Knowledge: Have insight into basic genomic testing concepts and terminology, as well as next-generation sequencing 3. Skills: Able to compare pharmacogenetic tests and assess clinical utility 4. Skills: Have methodological insight on how to best identify known heterogeneity within a disease or population and use this information to guide clinical management 5. Skills: Assess the spectrum, prevalance, and impact of mutation(s) on protein function 6. Competences: To put personalised medicine into a larger societal context complementing scientific considerations with economical, legal, and ethical perspectives 7. Competences: Insight into pharmacogenomics and theorise from these data a suitable therapeutic approach and computational drug discovery 8. Competences: Explain driver mutations and companion diagnostics Content Personalised medicine (PerMed) is a cross-cutting field that draws on expertise and data from very different disciplines and sectors. PerMed is defined in the European Council Conclusion on personalised medicine for patients (2015/C 421/03) as: “[…] it is widely understood that personalised medicine refers to a medical model using characterisation of individuals’ phenotypes and genotypes (e.g. molecular profiling, medical imaging, lifestyle data) for tailoring the right therapeutic strategy for the right person at the right time, and/or to determine the predisposition to disease and/or to deliver timely and targeted prevention.” Personalised Medicine requires a specific set of knowledge and skills including insight into genomic analysis, rational drug design and their implementation for tailored medical treatments. The course is structured in lectures, guided discussions, and related specific practical exercises, and will cover the following topics: • Human genome structure and importance of genome dynamics in the context of human disease • Genetic variation & genetic disease: Concepts of pathological variations and clinical implications. • Pharmacogenetics and pharmacogenomics: Adapting genetic knowledge to personalised diagnosis, prognosis, and treatment • PerMed in the context of drug discovery, clinical development, production & manufacturing, pharmacology, and structure biology • Systems pharmacology and pharmacometrics to understand variability in drug response • Targeted therapeutics, companion diagnostics, and advanced genome therapeutics • RCTs and clinical trials in PerMed • Pharmacovigilance: Register-based data for personalised and stratified medicine • Cancer biology & cancer genetics • Omics methods to enable the selection of optimal screening strategies, interventions or therapies • Legal & ethical issues of PerMed • Health economical aspects including reimbursement and market access Venue for the course will be located at the Department of Drug Design and Pharmacology. Basic knowledge of molecular biology is an advantage but not mandatory. Common lunch and coffee/refreshments during breaks are included. Participants PhD students across multiple fields with an interest in personalised medicine Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: Pharmaceutical Sciences (Drug Research Academy) All graduate programmes Language English Form The course consists of lectures, group work, and workshops, presentations and discussions. Course director José Moreira, Professor, Department of Drug Design and Pharmacology, jomo@sund.ku.dk Alexander S. Hauser, Associate Professor, Department of Drug Design and Pharmacology, alexander.hauser@sund.ku.dk Teachers José Moreira, Professor, Department of Drug Design and Pharmacology Alexander Hauser, Associate Professor, Department of Drug Design and Pharmacology Volker Lauschke, Karolinska Institutet, Sweden Christiane Gasse, Institute of Clinical Medicin, Aarhus University Jan Trøst Jørgensen, Director – Dx-Rx Institute Anders Hviid, Professor Statens Serum Institut Kristoffer Rohrberg, Head of the Phase 1 Unit at Rigshospitalet Rasmus Wolf (medicinraadet) Marianne Andersen - Novo Nordisk A/S Katharina Ó Cathaoir - Associate Professor - Faculty of Law Jukka Rantanen, Professor, Department of Pharmacy Miriam Kolko, Professor MSO, Department of Drug Design and Pharmacology Flemming Steen Jørgensen, Professor, Department of Drug Design and Pharmacology Albert Jelke Kooistra, Assistant Professor, Department of Drug Design and Pharmacology Maurizio Sessa, Assistant Professor, Department of Drug Design and Pharmacology Charlotte Vermehren, Associate Professor, Department of Drug Design and Pharmacology Trine Meldgaard Lund, Associate Professor, Department of Drug Design and Pharmacology Dates 20-27 March 2023 Course location PharmaSchool, University of Copenhagen, Universitetsparken 2/Jagtvej 160, 2100 Copenhagen Registration Please register before 1 February 2023 Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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