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Mass Spectrometry analysis of glycoproteins and glycoconjugates
Provider: Faculty of Health and Medical Sciences

Activity no.: 3427-23-00-00 
Enrollment deadline: 30/04/2023
Date and time22.05.2023, at: 09:00 - 26.05.2023, at: 16:00
Regular seats20
Course fee9,960.00 kr.
LecturersSergey Vakhrushev
ECTS credits3.70
Contact personSergey Vakhrushev    E-mail address: seva@sund.ku.dk
Enrolment Handling/Course OrganiserPhD administration     E-mail address: phdkursus@sund.ku.dk

Aim and content
This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD Students from NorDoc member universities. All other participants must pay the course fee.

Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from NorDoc member universities. After the enrollment deadline, available seats will be allocated to applicants on the waiting list.


Course description
Applications of analytical and synthetic chemistry are fundamental to elucidating the structures and expression patterns of complex biological molecules such as proteins and glycoconjugates, and understanding their functional interactions in order to exploit them effectively as targets of novel diagnostic and therapeutic strategies.

This course is intended as an introductory survey of instrumental and chemical techniques currently being applied to proteomics, glycomics, and glycoproteomics, and to biological problems involving protein-carbohydrate interactions.

The practical course will include mass spectrometry (MS) applied to the peptide and protein analysis (bottom up and Intact MS), with a special focus on key post-translational modifications (PTMs), including N- and O-linked glycosylation. Coverage will include sample preparation, new developments in fragmentation of peptides and glycans for determination of sequence and PTM site occupancy, high throughput applications, biomarker analysis, bottom up and Intact MS analysis, the basics glycoproteomics data analysis.


Learning objectives
Students should expect to get an overview of carbohydrate structure and interactions, especially as these apply to glycoprotein biosynthesis and function; particular focus will be placed on current methods for detailed analysis of protein glycosylation, and for studying the impact of glycosylation on protein functional interactions.


Content
The following topics are covered on the course
- General introduction to glycobiology
- Glycoproteomics
- Mass spectrometry
- Glycoinformatics
- Glycan analysis


Participants
PhD students engaged in projects that require knowledge of the structural chemistry and intermolecular interactions of glycoconjugates, current methods for analysis of protein glycosylation, and their applications in the field of biomedicine.


Relevance to graduate programmes

The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH:

All graduate programmes


Language
English


Form
Lectures, discussions, exercises and demonstrations


Course director
Sergey Vakhrushev
Associate professor, Copenhagen Center for Glycomics, Institut for Cellulær og Molekylær Medicin, seva@sund.ku.dk


Teachers
Sergey Vakhrushev, CCG and invited lecturers


Dates
22 – 26 May 2023


Course location
Panum, Maersk Tower, 10th floor


Registration
Please register before 30 April 2023

Admission to PhD students from Danish and Swedish Universities will be allocated on a first-come, first-served basis and according to the rules in force.
Applications from other participants will be considered after the last day of enrollment.




Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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