Graduate School of health and Medical Sciences

Magnetic Resonance Imaging in clinical neuroscience - potential & pitfalls
Provider: Faculty of Health and Medical Sciences

Activity no.: 3179-23-00-00
	Enrollment deadline: 13/03/2023

Date and time	27.03.2023, at: 08:00 - 31.03.2023, at: 15:45
Regular seats	20
Course fee	6,240.00 kr.
Lecturers	Hartwig Siebner
ECTS credits	4.00

Contact person	Susanne Steffensen E-mail address: susannes@drcmr.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD Students from NorDoc member universities. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from NorDoc member universities. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1. have insight into basic principles underpinning MR-based brain mapping techniques. 2. understand how MR-based brain mapping can capture BRAIN PATHOLOGY (e.g., neurodegeneration, neuroinflammation), PATHOGENESIS and PATHOPHYSIOLOGY (e.g., circuit dysfunction, aberrant brain development and plasticity) 3. be able to reflect on how decisions related to data acquisition, pre-processing and analysis methods will frame the clinical outcomes that can be obtained by MRI 4. put into perspective key concepts of MRI-based biomarkers and precision medicine 5. be able to design, and critically assess and interpret an MRI study of a brain disorder Content Disability caused by brain disorders is a top healthcare challenge, and the societal burden of brain disorders continues to increase as populations are aging. Magnetic Resonance Imaging (MRI) is the premier technique for non-invasive brain imaging. A large array of MRI technologies is available that can detect disease-related changes already at an early stage and monitor their dynamics in the individual brain. Its unmatched resolution and versatility render MRI indispensable for the diagnosis and medical care of citizens living with a brain disorder. In this course, we will focus on neuroscientific applications of MRI in clinical brain research and only give a coarse introduction in MR-physics and technology. We will take a mechanism-centered and conceptual perspective to explore together how MRI can contribute to clinical neuroscience. We will ask which mechanisms (e.g., inflammation, degeneration, trauma, impaired perfusion) affect brain function and how these disease-inducing mechanisms and the resulting consequences can be captured with MRI-based techniques at the macrostructural, microstructural, functional and metabolic level, highlighting their potential, limitations, and methodological pitfalls. In morning sessions, we will introduce key “read-outs” of brain pathology (e.g., atrophy, network dysfunction) and how these read-outs can be best revealed by MR-based brain mapping in clinical brain research. The afternoon sessions will mainly involve group work during which participants will practically apply the knowledge and concepts presented during the morning sessions. Day 1: Macrostructural brain MRI: Atrophy and lesions and macrostructural connectomics Day 2: Microstructural brain MRI: Tissue damage in the “normal-appearing” brain and tract-based structural connectomics Day 3: Functional brain MRI: Probing alteration in functional brain activity and connectomics Day 4: Metabolic / spectroscopic MR of the brain: Neurometabolic profiling Day 5: Multimodal integration for multi-parametric assessment of pathology Participants PhD students (e.g., medicine, neuroscience, psychology, engineering, humanities) interested in brain and behavioural changes across the life span, in health and disease. No specific qualifications required. Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: Medical and Molecular Imaging Neuroscience Psychiatry Language English Form Interactive lectures in the morning and group work in the afternoon Course directors Hartwig Siebner, Professor, h.siebner@drcmr.dk DRCMR, Hvidovre Hospital (HVH) Dept. of Neurology, Bispebjerg Hospital Institute of Clinical Medicine, University of Copenhagen David Meder, Senior researcher (DRCMR, HvH), davidm@drcmr.dk Henrik Lundell, Senior researcher (DRCMR, HvH), lundell@drcmr.dk Kathrine Madsen, Senior researcher (DRCMR, HvH), kathrine@drcmr.dk Kristoffer Madsen, Assoc. Prof. (DTU-Compute), Senior researcher (DRCMR, HvH), kristofferm@drcmr.dk Vanessa Wiggermann, PostDoc (DRCMR, HvH), vanessaw@drcmr.dk Course secretary Susanne Steffensen, susannes@drcmr.dk, Tel: +45 38621184, DRCMR, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Kettegård Allé 30, DK-2650 Hvidovre Teachers The course directors and… Andrew Zalewsky, Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Australia Carl-Johan Boraxbekk, Professor, CJ@drcmr.dk, (DRCMR, HvH, Dept. of Neurology, Bispebjerg Hospital, & Institute of Clinical Medicine, University of Copenhagen) Kristian Mortensen, PostDoc, (DRCMR, HvH) Mads AJ Madsen, PostDoc, (DRCMR, HvH) Markus Nilsson, Professor, Lund University Michal Povazan, Research fellow (DRCMR, HvH) Naiara Demnitz, PostDoc (DRCMR, HvH) Nathalie Just, Research fellow (DRCMR, HvH) Oliver Hulme Associate Professor (Dept. of Psychology, Copenhagen University), Senior researcher (DRCMR, HvHl) Petr Bednarik, Radiologist (Radiology Section, HvH), Research fellow (DRCMR, HvH) Søren Asp Fuglsang, PostDoc (DRCMR, HvH) Tim Dyrby, Associate Professor (DTU-Compute), Senior researcher (DRCMR, HvH) William Barré, Senior researcher (DRCMR, Hvidovre Hospital) Facilitators (Group work) Anna Plachti, PostDoc (DRCMR, Hvidovre Hospital) Kristian Nygaard Mortensen, PostDoc (DRCMR, Hvidovre Hospital) Melissa Larsen, Research fellow (DRCMR, Hvidovre Hospital) Naiara Demnitz, PostDoc (DRCMR, HvH) Simon Steinkamp, PostDoc (DRCMR, HvH) Dates Week 13, 27-31 March 2023 Course location Auditorium 3-4 Hvidovre Hospital Kettegård Allé 30 DK-2650 Hvidovre Denmark Registration Please register before 13 March 2023. Expected frequency Every 2-3 years. Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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