Graduate School of health and Medical Sciences

Genome Maintenance and Diseases
Provider: Faculty of Health and Medical Sciences

Activity no.: 3252-24-00-00
	Enrollment deadline: 22/10/2024

Date and time	18.11.2024, at: 09:00 - 21.11.2024, at: 19:30
Regular seats	25
Course fee	5,280.00 kr.
Lecturers	Claus Sørensen
ECTS credits	2.90

Contact person	MoMed Team E-mail address: momed@bric.ku.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD Students from NorDoc member faculties. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from NorDoc member faculties. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1. Understand and describe the main pathways of genome maintenance and their molecular links to cancer and other human diseases 2. Understand the benefits and limitations of different model systems and technologies to study genome maintenance processes 3. Analyze experimental data and communicate scientific hypothesis and results 4. Gain a broad perspective of how basic research can be translated into the clinic Content 1. Introduction to genome maintenance pathways and diseases 2. Mechanisms and experimental methods: - DNA Replication stress, protein signaling, and DNA damage response - Imaging, DNA sequencing, structural, and screening technologies 3. Physiology and model organisms: - Modeling genome maintenance diseases in mice - Genome instability in germline cells 4. From basic research to the clinic: - Drug design, validation, and approval - Novel technologies in disease diagnosis - Disease treatment Participants Participants must be enrolled in a graduate program at the Faculty of Health and Medical Science and have an interest in mechanisms of genome maintenance and diseases. Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: Molecular Mechanisms of Disease All graduate programmes Language English Form Lectures Group work and discussions Course director Claus Storgaaard Sørensen, Professor, BRIC, University of Copenhagen, claus.storgaard@bric.ku.dk Niels Mailand, Professor, NNF center for Protein Research, University of Copenhagen, niels.mailand@cpr.ku.dk Julien Duxin, Associate Professor, NNF center for Protein Research, University of Copenhagen, Julein.duxin@cpr.ku.dk Teachers (subject to change) Eva Hoffmann, Professor, Center for Chromosome Stability, University of Copenhagen Haico van Attikum, Professor, Leiden University Medical Center, The Netherlands Thomas Miller, Associate Professor, Center for Chromosome Stability, University of Copenhagen Fran Supek, Professor, BRIC, University of Copenhagen Fena Ochs, Associate Professor, BRIC, University of Copenhagen Andrés López-Contreras, CABIMER, Sevilla, Spain Kim Theilgaard-Mønch, Professor, BRIC, University of Copenhagen Arne Nedergaard Kousholt, VUS diagnostics, The Netherlands Andrew Jackson, Professor, University of Edinburgh Dates 18-21 November 2024 Course location Panum/BRIC (TBA) Registration Please register before 22 October 2024 Expected frequency Once every 3 years Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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