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Drug Delivery
Provider: Faculty of Health and Medical Sciences
Activity no.: 3115-25-00-00
There are 19 available seats
Enrollment deadline: 01/04/2025
Date and time
19.05.2025, at: 09:00 - 23.05.2025, at: 15:00
Regular seats
30
Course fee
5,400.00 kr.
Lecturers
Camilla Foged
ECTS credits
4.20
Contact person
Marianne W. Jørgensen E-mail address: marianne.joergensen@sund.ku.dk
Enrolment Handling/Course Organiser
PhD administration E-mail address: phdkursus@sund.ku.dk
Aim and content
This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD Students from NorDoc member faculties. All other participants must pay the course fee.
Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from NorDoc member faculties. After the enrollment deadline, available seats will be allocated to applicants on the waiting list.
Learning objectives
The course objectives are:
1. to give participants an in-depth overview of important fundamental principles for drug delivery
2. to present methodologies for optimizing delivery of different drug classes ranging from small molecules to complex biopharmaceuticals (peptides, proteins, nucleic acids and vaccines).
Content
One of the main scientific challenges in pharmaceutical development is to deliver the drug compound in a controlled way at the site of action in a therapeutically optimal amount to obtain the desired pharmacological effect. Drug delivery is challenged by the existence of a variety of barriers related to either intrinsic drug characteristics and/or to the physiological environment in the body. It is essential to have a basic understanding of the extent to which these barriers affect the drug bioavailability, i.e. the relative rate and amount of the drug which reaches the target site.
An undesired low bioavailability may be a result of the presence of physiological or metabolic barriers, which a drug compound has to overcome before reaching the target site. Additional hurdles for drug delivery are e.g. an unfavorable biodistribution profile of the drug, physico-chemical drug properties, and a suboptimal pharmaceutical formulation.
Approaches to overcome barriers of drug delivery include the choice of administration route as well as formulation design.
When optimizing drug delivery it is important to obtain a fundamental knowledge of the complex drug release characteristics in biological environments, biotransformation, as well as drug transport to the target site. A more rational design of drug compounds and pharmaceutical delivery systems is also enabled by a better understanding of the structural and dynamic functions of biological membrane barriers, e.g. the interplay between lipid bilayer structure, specific membrane transporters and drug molecules or excipients.
The course will cover the following key topics:
• Biological barriers and administration routes
• Metabolic barriers
• Physicochemical characteristics of drug substances
• Advanced drug delivery systems, targeting and stimuli-triggered release (e.g. lipid- and polymer-based delivery systems)
• Delivery of small molecule drugs (e.g. poorly soluble drugs and pro-drugs)
• Delivery of biopharmaceuticals (e.g. peptides, proteins, nucleic acids and vaccines)
• Membrane biophysics in drug delivery
• Imaging in drug delivery
• Industrial perspectives on drug delivery
• Safety and toxicity of nanocarrier systems
• The use of in vitro and in vivo models in drug delivery
Participants
The course is mainly offered to PhD students who have completed undergraduate courses in pharmaceutics, chemistry or biology.
Relevance to graduate programmes
The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH:
Pharmaceutical Sciences (Drug Research Academy)
Language
English
Form
Lectures, group work, writing of report, preparation
Course director
Camilla Foged, Professor, Department of Pharmacy, camilla.foged@sund.ku.dk
Teachers
Camilla Foged, Professor, UCPH-SUND
Federica Sebastiani, Assistant Professor, UCPH-SUND
Hanne Mørck Nielsen, Professor, UCPH-SUND
Ben Boyd, Professor, UCPH-SUND
Anette Müllertz, Professor, UCPH-SUND
Abhijeet Girish Lokras, Post doc, UCPH-SUND
Martin Malmsten, Professor, UCPH-SUND
Stephen Buckley, Head of ADME Department, Novo Nordisk A/S
Birger Brodin, Professor, UC-SUND
Marco van de Weert, Associate Professor, UC-SUND
Nina Østergaard Knudsen, Riemann
Rene Holm, Professor, SDU
Ken Howard, Aarhus University
Thomas Rades, Professor, UC-SUND
Dates
19-23 May 2025
Course location
PharmaSchool, Universitetsparken 2/Jagtvej 160, 2100 Copenhagen O
Registration
Please register before 1 April 2025
Expected frequency
Once a year
Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules.
Applications from
Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.
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