Graduate School of health and Medical Sciences

Basic Glycobiology
Provider: Faculty of Health and Medical Sciences

Activity no.: 3428-25-00-00	There are 19 available seats
	Enrollment deadline: 01/09/2025

Date and time	20.10.2025, at: 10:00 - 24.10.2025, at: 17:00
Regular seats	20
Course fee	14,280.00 kr.
Lecturers	Katrine Schjoldager Yoshiki Narimatsu
ECTS credits	4.50


Enrolment Handling/Course Organiser	PhD administration SUND E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD Students from NorDoc member faculties. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student at a Danish university, you will be placed on the waiting list until enrollment deadline. This also applies to PhD students from NorDoc member faculties. After the enrollment deadline, available seats will be allocated to applicants on the waiting list. COURSE DESCRIPTION This course is designed as a basic introduction to the structures, biosynthesis, and functions of complex carbohydrates. Protein glycosylation in eukaryotes is one of the most common forms of posttranslational modification, and complex carbohydrates on glycoproteins, glycosaminoglycans and glycolipids play key roles in various biological processes. Throughout the course, glycosylation processes in the eukaryotic cell will be in focus, with a particular emphasis on genetic engineering of glycogenes and recombinant expression of glycoproteins. The course will provide the students with insights into the structure and function of glycoconjugates and carbohydrate-binding proteins, with examples of their roles in both normal and disease states. The practical component will involve working with a cell-based glycan array, based on stable glycoengineered libraries of isogenic HEK293 cells with loss or gain of glycosylation features. The students will use this library to dissect molecular interactions with reagents that bind glycans (e.g., lectins, antibodies, and other receptors). Additionally, students will practice assessing gene KO efficiency using a simple PCR-based method, indel detection by amplicon analysis (IDAA). The practical course will also include hands-on use of reagents (lectins, antibodies, enzymes) and methods (flow cytometry, PCR, fragment analyzer) employed to characterize carbohydrates. A deeper and broader theoretical understanding of the critical biological functions of carbohydrates and glycoproteins will be provided through lectures by national and international experts, with particular emphasis on the connection between glycosylation defects and human diseases. Course title Glycobiology Learning objectives The objectives of the course are to provide students with a basic introduction to the structures, biosynthesis, and functions of complex carbohydrates. Additionally, the course will offer insight into the structure and function of carbohydrate-binding proteins and provide examples of their roles in normal and disease states A student who has met the objectives of the course will be able to: 1. Describe the major mammalian glycosylation pathways 2. Describe the biosynthetic complexity of the major glycosylation pathways 3. Describe ways of identifying the most common mammalian glycan structures Content The following topics are covered on the course: General introduction to glycobiology, glycotechnology and glycogenetics, glycan function, glycosylation and diseases, carbohydrate binding molecules and glycan analysis, Participants No particular requirements Language English Form Lectures, discussions, exercises and demonstrations Course directors Yoshiki Narimatsu Associate professor, Copenhagen Center for Glycomics, Institut for Cellulær og Molekylær Medicin, yoshiki@sund.ku.dk and Katrine Schjoldager Associate professor, Copenhagen Center for Glycomics, Institut for Cellulær og Molekylær Medicin,, schjoldager@sund.ku.dk Teachers TBD Dates 20 – 24 October 2025 Course location Panum, Mærsk Tower, 10th floor Registration Please register before 1 September 2025 Expected frequency Every second year Seats to PhD students from other Danish and Swedish universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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