Login for PhD students at UCPH      Login for others
In Vivo Pharmacology - Biologic variation, reproducibility and predictability in preclinical drug testing in lab. animal
Provider: Faculty of Health and Medical Sciences

Activity no.: 3120-15-00-00 
Enrollment deadline: 01/06/2015
Date and time22.06.2015, at: 09:00 - 28.08.2015, at: 16:00
Regular seats25
Course fee5,040.00 kr.
LecturersJens Lykkesfeldt
ECTS credits6.00
Contact personHelle Lohmann Schøler    E-mail address: hlsc@sund.ku.dk
Enrolment Handling/Course OrganiserPhD administration     E-mail address: fak-phdkursus@sund.ku.dk

Aim and content
Learning objective
A student who has met the objectives of the course will be able to:

a. Understand the basic theoretical foundation on in vivo pharmacological testing including both screening and confirmatory methods
b. Apply knowledge of and discuss biological and experimental variation, reproducibility and predictability related to animal experiments
c. Engage in designing laboratory animal experiments.
d. Discuss and reflect on validity of animal models of human disease

Content
Experimental research in animals is justified due to its expected predictability of conditions in other species. Within the same species and even within the same strain or substrain of a species, the variation can be large. This phenotypic variation is not only ruled by the genotype but also by environmental factors as simple as housing conditions, feeding and microbiological status. Integration of study results obtained by animal experimentation is generally accepted as valid. However, due to many factors influencing the experimental outcome, contradictory results may be obtained and sometimes great difficulties have been experienced in reproducing results obtained by other investigators.

The uncertainties in animal characteristics and testing conditions so far have not hindered the insight into biological regulatory mechanisms. However, if animal studies should have the highest degree of predictability and reproducibility, only animals of well-defined health status housed under well-defined conditions should be used. In vivo drug testing should be planned in order to eliminate the variation caused by improper standardisation from group to group or over time and the bias caused by erroneous techniques.

This course will highlight the various factors that are critical for variation and thereby for the reproducibility and predictability in experimental research in animals. The factors are many and some are more important than others. The importance may vary with the goal and design of the study. It is the responsibility of the scientists to take these factors into consideration in order to produce data that offer minimal experimental variation and maximal reproducibility. Taking this responsibility seriously will not only improve drug testing, but it will also be in accordance with the ethical obligation to gain as much information as possible whenever using animals for experiments.

Covered topics include:
• In vivo models in pharmacology and toxicology
• Experimental design
• Validity of animal models
• Variation in animal experiments: Factors related to the animal
• Variation in animal experiments: Factors related to the environment
• Variation in animal experiments: Experimental factors
• New tools and clinical perspectives


Participants
The course is relevant for student with a veterinary, medical or natural science degree planning to do animal experiments or enrolled in the In Vivo Pharmacology PhD program. It is an advantage to have passed the Laboratory animal science course or equivalent.

Language
English

Form
Lectures, exercises, discussions, poster presentations and group work. In addition, substantial self-study, preparation of poster with an in vivo pharmacological perspective, and evaluation of fellow student’s work is included.

Course director
Professor Jens Lykkesfeldt, Department of Veterinary Disease Biology, Section of Experimental Animal Models, Frederiksberg Campus, KU-SUND, E-mail: jopl@sund.ku.dk

Teachers
Teachers from both academia and pharmaceutical industry

Course secretary
Helle Lohmann Schøler, hlsc@sund.ku.dk

Dates
Part 1: 22/6 - 26/6 2015 Part 2: Poster session and examination 24/8 & 26/8 2015


Course location
KU-SUND, Frederiksberg Campus

Registration: Please register before (01.06.2015)

Admission to PhD students from Danish universities will be allocated on a first-come, first-served basis and according to the rules in force.
Applications from other participants will be considered after the last day of enrollment.


Search
Click the search button to search Courses.


Course calendar
See which courses you can attend and when
JanFebMarApr
MayJunJulAug
SepOctNovDec



New courses
Courses are published regularly. High demand courses are announced 15 November 2017 at 9 am and 2 May 2018. 


Learn which courses are announced on fixed dates