Graduate School of health and Medical Sciences

Anatomical and physiological fingerprinting of the human brain with multi-modal MRI
Provider: Faculty of Health and Medical Sciences

Activity no.: 3474-18-00-00
	Enrollment deadline: 26/01/2018

Date and time	26.02.2018, at: 09:00 - 02.03.2018, at: 17:00
Regular seats	20
Course fee	3,480.00 kr.
Lecturers	Tim B. Dyrby
ECTS credits	4.40

Contact person	Susanne Steffensen E-mail address: susannes@drcmr.dk

Enrolment Handling/Course Organiser	PhD administration E-mail address: phdkursus@sund.ku.dk

Aim and content This course is free of charge for PhD students at Danish universities (except Copenhagen Business School). Special rules apply for research year students enrolled at Faculty of Health and Medical Sciences at UCPH. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student, you will be placed on the waiting list for the course until enrollment deadline. After the deadline of enrollment, available seats will be allocated to students on the waiting list. Learning objectives A student who has met the objectives of the course will be able to: 1. Describe and understand the basic principles of an MRI scanner and the possibilities in using ultra-high-field MRI. 2. Explain and understand central sequences and experimental concepts for neurovascular MRI, quantitative MRI, diffusion MRI and spectroscopy. 3. Characterize the MRI signal contrast obtained from neurovascular MRI, quantitative MRI, diffusion MR and spectroscopy in relation to the true underlying physiological and microstructural environment. 4. Justify multimodal MRI experiments and identify relevant data analysis and modelling strategies to map a biological functional, microstructural and metabolic feature in tissue. Content The PhD course provides an overview on how Magnetic Resonance Imaging (MRI) can be used in neuroimaging. Four cutting edge MRI topics will be introduced, addressing the increasing need for combining several MRI modalities. It covers how to 1) improve the specificity for mapping anatomical features for precision medicine, and 2) create a better link between brain structure and function, which is partly missing today. The four MRI topics covered are: Neurovascular contrast imaging, Quantitative MRI, Diffusion MRI and Spectroscopy. The possibilities of using the Danish National Ultra-High Field human 7T MRI will be integrated within the lectures. The course combines lectures and practical hands-on exercises for introducing the participants to the state-of-art experimental designs within each of the topics, their possibilities and challenges. Exercise presentations and discussions between participants are emphasized. International keynote speakers will inspire the discussions of multi-modal imaging within the four MRI topics. With emphasis on each of the MRI modalities we will cover the topics: • Introduction to MRI: How does a MRI scanner work? Basic tissue contrast mechanisms, T1 and T2 relaxation useful for tissue characterization, Ultra-High Field MRI (7 tesla) and MR safety. • Functional MRI: Blood-oxygen-level dependent contrast imaging (BOLD) and Arterial Spin labelling (ASL) for hemodynamic assessment of changes in CBF, CBV, OEF and CMRO2 during neural activation, potential and analysis. • Quantitative MRI: T1/T2/T2* relaxations, magnetization transfer, susceptibility weighted imaging, analysis and tissue compartment modelling. • Diffusion MRI: Basic diffusion concepts, non-parametric (diffusion tensor and kurtosis imaging) and parametric tissue compartment models e.g. axon diameters, diffusion sequences, tractography, pre-processing pipeline. • Spectroscopy: Basic spectroscopy concepts, detectable metabolites and their significance, acquisition strategies (water suppression, single voxel, spectroscopic imaging), data processing/analysis, quantification, multinuclear spectroscopy. Participants The target participants are PhD students with interest in neuroscience, clinical research as well as those more technically interested in neuroimaging. It is beneficial but not required having insights into basic MRI. Students need to study provided material in advance to follow the introductory MRI lectures. Relevance to graduate programmes The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH: Neuroscience Medical and Molecular Imaging Clinical Research Language English Form Lectures and practical hands-on sessions and discussions Course director Tim B. Dyrby, Assoc. Professor, timd@drcmr.dk (Danish Research Centre for Magnetic Resonance (DRCMR), Copenhagen University Hospital Hvidovre, Denmark, and Technical University of Denmark) Hartwig R. Siebner, Professor, hartwig.siebner@drcmr.dk (Danish research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, and University of Copenhagen) Teachers Faculty will include researchers from DRCMR and invited international keynote speakers to be confirmed. • Axel Thielscher, DRCMR, and DTU • Hartwig R. Siebner, DRCMR and KU • Kristoffer H. Madsen, DRCMR and DTU • Esben Thade Petersen, DRCMR, and DTU • Tim B. Dyrby, DRCMR, and DTU • Lars Hanson, DRCMR, and DTU • Henrik Lundell, DRCMR • Nina Reislev, DRCMR • Kasper W. Andersen, DRCMR • Anouk Marsman, DRCMR • Vincent Boer, DRCMR Dates Monday 26th February – Friday 2nd March 2018 Course location Copenhagen University Hospital Hvidovre, Danish Research Centre for Magnetic Resonance, Section 714, Hvidovre, Denmark Registration Please register before 26 January 2018 Seats to PhD students from other national and international universities will be allocated on a first-come, first-served basis and according to the applicable rules. Applications from other participants will be considered after the last day of enrolment. Exam: Written report graded as pass/fail with internal censoring

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