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Gene Targeting and Editing
Provider: Faculty of Health and Medical Sciences

Activity no.: 3408-19-00-00 
Enrollment deadline: 15/07/2019
Date and time19.08.2019, at: 09:00 - 30.08.2019, at: 17:00
Regular seats25
Course fee14,640.00 kr.
LecturersPeter E. Nielsen
ECTS credits7.00
Contact personPeter E. Nielsen    E-mail address: ptrn@sund.ku.dk
Enrolment Handling/Course OrganiserPhD administration     E-mail address: fak-phdkursus@sund.ku.dk

Aim and content
This course is free of charge for PhD students at Danish universities (except Copenhagen Business School), and for PhD students at graduate schools in the other Nordic countries. All other participants must pay the course fee.
Anyone can apply for the course, but if you are not a PhD student, you will be placed on the waiting list for the course until enrollment deadline. After the deadline of enrollment, available seats will be allocated to students on the waiting list.

Learning objectives
A student who has met the objectives of the course will be able to:

1. Understand state of the art Gene Targeting and Editing technology
2. Design and perform Gene Targeting and Editing experiments
3. Analyse results from Gene Targeting and Editing experiments
4. Explain principles and use of CRISPR technology
5. Explain principles and use of antisense and siRNA technology


Content
Experimentally, the following (cell culture) techniques will be taught via laboratory exercises: 1. Gene knockout and knock in by CRISPR and zinc finger nuclease (ZNF) technology. 2. Gene silencing by siRNA technology. 3. mRNA splicing modulation by antisense technology. 4. Prodrug technology by gene therapy. A deeper and broader theoretical understanding of the techniques and their (potential) applications is offered via lectures by national and international experts in the field combined with active group work.
Describe the course curriculum in terms of scientific topics covered.

Participants
The course is relevant for medical, pharmaceutical, veterinarian and biology students with a broad background in molecular and cell biology as well as some laboratory experience.


Relevance to graduate programmes
The course is relevant to PhD students from the following graduate programmes at the Graduate School of Health and Medical Sciences, UCPH:

Cellular and Genetic Medicine
Molecular Mechanisms of Disease
Veterinary and Animal Sciences


Language
English

Form
Laboratory exercises, lectures, group work, discussions


Course director
Prof. Peter E. Nielsen, ICMM; ptrn@sund.ku.dk


Teachers
Assoc. Prof. Eric Paul Bennet, Department of Odontology; epb@sund.ku.dk, Assoc. Prof. Niels Erik Møllegaard, ICMM; nielsem@sund.ku.dk, a.o.

Dates
August 19-30, 2019

Course location
Panum Institute


Registration
Please register before July 15, 2019

Seats to PhD students from other Danish universities will be allocated on a first-come, first-served basis and according to the applicable rules.
Applications from other participants will be considered after the last day of enrolment.

Formel requirements
Qualifications required:

Reasonable hands on experience in general molecular biology (for instance corresponding to the course “Basic Gene Technology”)

Note: All applicants are asked to submit invoice details in case of no-show, late cancellation or obligation to pay the course fee (typically non-PhD students). If you are a PhD student, your participation in the course must be in agreement with your principal supervisor.

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