Graduate School of health and Medical Sciences

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Human Digestion and Absorption - a mechanistic understanding
Provider: Faculty of Health and Medical Sciences

Activity no.: 3117-16-00-00	There are no available seats
	Enrollment deadline: 01/03/2016

Date and time	11.04.2016, at: 09:00 - 15.04.2016, at: 16:00
Regular seats	18
Course fee	3,960.00 kr.
Lecturers	Anette Müllertz
ECTS credits	4.60

Contact person	Janne Steen Kjærulf E-mail address: janne.kjaerulff@sund.ku.dk

Enrolment Handling/Course Organiser	PhD administration SUND E-mail address: phdkursus@sund.ku.dk

Enrolment guidelines This course is free of charge for PhD students at Danish universities (except Copenhagen Business School). Special rules apply for research year students enrolled at Faculty of Health and Medical Sciences at UCPH. All other participants must pay the course fee. Anyone can apply for the course, but if you are not a PhD student, you will be placed on the waiting list for the course until enrollment deadline. After the deadline of enrollment, available seats will be allocated to students on the waiting list. Learning objectives A student who has met the objectives of the course will: a. Achieve a detailed insight into the anatomy and physiology gastro-intestinal tract, and its role in solubilization and absorption of bioactives and drugs. b. Understand the physiological effects of food intake and the influence of food intake on drug absorption. c. Get the ability to develop a drug delivery system suitable for drug delivery to a specific location in the GI tract, e.g. the colon. d. Have an overall understanding of the role of microbiota in health and disease, and the potential influence on drug delivery. e. Be able to select an suitable in vitro model for development of an oral delivery system. Content Although oral drug delivery is the most common and convenient way for patients to take medicine, the existence of a variety of enzymes and barriers in the gastrointestinal tract presents a challenge. When optimizing oral drug delivery systems, it is important to have a fundamental knowledge of digestive processes and the impact of intestinal fluid composition, the microbiota, as well as the intestinal immune system and barriers on the stability, dissolution and absorption of drugs. In addition, selecting suitable methodology and in vitro models for oral drug delivery will ensure success for in vitro and in vivo correlations. The lectures will cover the following key topics: • Organoleptic assessment of oral products • Gastrointestinal physiology • Characterization of gastric and intestinal fluids • Hydrodynamic conditions in the gastrointestinal tract and effect on transit time • Effect of food intake on transit time and gastrointestinal fluids • Understanding of digestive processes, enzymatic, pH-dependent, etc. • Mucosal barrier in gastrointestinal tract • Use of enhancers to increase absorption of nutrients and drugs • Lipid digestion, absorption and metabolism • Solubilization and emulsification of nutrients and pharmaceutical drugs • Encapsulation of nutrients and drugs • The gut microbiota – species and functionalities • Targeting and site-specific delivery • Delivery to the colon • Regional absorption and controlled release • Drug formulation principles • Suitable animal models for studies of human digestion and absorption • In vitro models simulating the digestion Participants The course is relevant for PhD students and others within life and medical sciences, who desires to get a better understanding of the human gastro-intestinal tract. Language English Please note that all courses have to be provided in English if required by non-Danish participants. Form It is a 5-day course comprising about 25 lectures and group work. The group work will be finalized with a presentation on the last day. Course directors Anette Müllertz, anette.mullertz@sund.ku.dk Huiling Mu, huiling.mu@sund.ku.dk Jette Jacobsen, jette.jacobsen@sund.ku.dk Daniel Bar-Shalom, Daniel.barshalom@sund.ku.dk Teachers Anette Müllertz Huiling Mu Jette Jacobsen Daniel Bar-Shalom Thomas Rades Peter Vilmann Jens Rikardt Andersen Hanne Frøkiær Thomas Leser m.fl. Course secretary Janne Steen Kjærulff; janne.kjaerulff@sund.ku.dk, 35336482 Dates 11-15 April, 2016 Course location ??? Universitetsparken 2 Registration: Please register before March 1st , 2016 Admission to PhD students from Danish universities will be allocated on a first-come, first-served basis and according to the rules in force. Applications from other participants will be considered after last day of enrollment..

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